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  Open access

December, 2020; 9 (12)

REVIEW

  • Open Access
    Recent developments of tools for genome and metabolome studies in basidiomycete fungi and their application to natural product research
    Fabrizio Alberti, Saraa Kaleem, Jack A. Weaver
    Biology Open 2020 9: bio056010 doi: 10.1242/bio.056010 Published 2 December 2020

    Summary: Fungi of the phylum Basidiomycota can make bioactive natural products. We discuss recent advances of tools for genome and metabolome studies that will facilitate natural product discovery and characterisation.

RESEARCH ARTICLES

  • Open Access
    The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome
    Ivo J. H. M. de Vos, Arnette Shi Wei Wong, Jason Taslim, Sheena Li Ming Ong, Nicole C. Syder, Julian L. Goggi, Thomas J. Carney, Maurice A. M. van Steensel
    Biology Open 2020 9: bio054270 doi: 10.1242/bio.054270 Published 29 December 2020

    Summary: We report a novel sh3pxd2b mutant zebrafish model that develops cutaneous and musculoskeletal fibrosis, similar to that observed in people with Frank-Ter Haar syndrome.

  • Open Access
    MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β
    Chi-Yung Chai, I.-Chun Tai, Rui Zhou, Junlong Song, Chaoying Zhang, Shengrong Sun
    Biology Open 2020 9: bio051904 doi: 10.1242/bio.051904 Published 21 December 2020

    Summary: Our findings provided a new role of miR-9-5p/PPAR in the occurrence and development of HS fibroblasts, promising a new target for HS.

  • Open Access
    Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
    Jared P. Taylor, Lucas H. Armitage, Daniel L. Aldridge, Melanie N. Cash, Mark A. Wallet
    Biology Open 2020 9: bio052969 doi: 10.1242/bio.052969 Published 21 December 2020

    Summary: The plant-derived compound harmine shows efficacy in enhancing the effects of existing HIV latency-reversing drugs.

  • Open Access
    Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite
    Malabika Chakrabarti, Deepika Kannan, Akshay Munjal, Hadi Hasan Choudhary, Satish Mishra, Shailja Singh
    Biology Open 2020 9: bio054544 doi: 10.1242/bio.054544 Published 21 December 2020

    Summary: Our study identifies the role of parasite chorismate synthase and salicylic acid on host immunopathology and disease manifestation in cerebral malaria and points towards a pathway associated with salicylic acid-mediated autophagy of the malaria parasite.

  • Open Access
    iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery
    Igor Gurevich, Sarah A. Burton, Christie Munn, Makiko Ohshima, Madelyn E. Goedland, Katherine Czysz, Deepika Rajesh
    Biology Open 2020 9: bio055087 doi: 10.1242/bio.055087 Published 16 December 2020

    Summary: We describe the development and validation of a hepatocyte differentiation protocol using iPSCs from a panel of NASH donors and healthy controls.

  • Open Access
    CD47 differentially regulates white and brown fat function
    Heather Norman-Burgdolf, Dong Li, Patrick Sullivan, Shuxia Wang
    Biology Open 2020 9: bio056747 doi: 10.1242/bio.056747 Published 16 December 2020

    Summary: Under physiological conditions, CD47 differentially regulates white fat and brown fat function. Through a coordinated manner, altered fuel availability via white adipose tissue lipolysis may influence brown adipose tissue energy expenditure and then body weight management.

  • Open Access
    Locomotor mechanism of Haplopelma hainanum based on energy conservation analysis
    Xin Hao, Wenxing Ma, Chunbao Liu, Zhihui Qian, Luquan Ren, Lei Ren
    Biology Open 2020 9: bio055301 doi: 10.1242/bio.055301 Published 7 December 2020

    Summary: For spiders, the bouncing gait and the hydraulic system contribute to the lower transport cost at low speed, while the hydraulic system greatly increases the transport cost at high speed.

  • Open Access
    Overexpression of an ALS-associated FUS mutation in C. elegans disrupts NMJ morphology and leads to defective neuromuscular transmission
    Sebastian M. Markert, Michael Skoruppa, Bin Yu, Ben Mulcahy, Mei Zhen, Shangbang Gao, Michael Sendtner, Christian Stigloher
    Biology Open 2020 9: bio055129 doi: 10.1242/bio.055129 Published 7 December 2020

    Summary: Neuronal expression of an ALS-associated mutation in a DNA/RNA-binding protein disrupts the organization and function of the C. elegans neuromuscular junction.

  • Open Access
    Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue
    Li-jie Wang, Tian Hsu, Hsiang-ling Lin, Chi-yu Fu
    Biology Open 2020 9: bio054262 doi: 10.1242/bio.054262 Published 3 December 2020

    Summary: Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue.

  • Open Access
    Informing epidemic (research) responses in a timely fashion by knowledge management – a Zika virus use case
    Angela Bauch, Johann Pellet, Tina Schleicher, Xiao Yu, Andrea Gelemanović, Cosimo Cristella, Pieter L. Fraaij, Ozren Polasek, Charles Auffray, Dieter Maier, Marion Koopmans, Menno D. de Jong
    Biology Open 2020 9: bio053934 doi: 10.1242/bio.053934 Published 2 December 2020

    Summary: The Zika KnowledgeBase collects and integrates literature and experimental data based on Zika virus pathobiology for future emerging epidemics.

FIRST PERSON

  • Open Access
    First person – Ivo de Vos
    Biology Open 2020 9: bio057935 doi: 10.1242/bio.057935 Published 29 December 2020
  • Open Access
    First person – Sebastian Markert
    Biology Open 2020 9: bio057760 doi: 10.1242/bio.057760 Published 7 December 2020
  • Open Access
    Future Leader to Watch – Fabrizio Alberti
    Biology Open 2020 9: bio057679 doi: 10.1242/bio.057679 Published 3 December 2020
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    A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology

    Jeffrey D. Hildebrand, Adam D. Leventry, Omoregie P. Aideyman, John C. Majewski, James A. Haddad, Nancy Kaufmann
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  • Open Access

    Quantified growth of the human embryonic heart

    Jaeike W. Faber, Jaco Hagoort, Antoon F. M. Moorman, Vincent M. Christoffels, Bjarke Jensen
    PDF
  • Open Access

    Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation

    Xin Huang, Sijia Wang, Li Jin, Yungang He
    PDF
  • Open Access

    Auxin confers protection against ER stress in Caenorhabditis elegans

    A. Bhoi, F. Palladino, P. Fabrizio
    PDF
  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
    PDF
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