RESEARCH ARTICLES
- Tubulin-binding cofactor E-like (TBCEL), the protein product of the mulet gene, is required in the germline for the regulation of inter-flagellar microtubule dynamics during spermatid individualization
Summary: The leading cause of human male infertility is a failure to resolve spermatids from a germline syncytium during spermatid individualization. Here we characterize a mutation that disrupts this process.
- Heart rate and cardiac response to exercise during voluntary dives in captive sea turtles (Cheloniidae)
Summary: Green turtles showed immediate cardiac response to exercise during submergence, presumably because they store oxygen primarily in the lungs and need blood circulation to meet the metabolic demand.
- TRBP–Dicer interaction may enhance HIV-1 TAR RNA translation via TAR RNA processing, repressing host-cell apoptosis
Summary: HIV-1 RNA translation may be enhanced through TAR RNA processing by TRBP in collaboration with Dicer, repressing host–cell apoptosis.
- Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4
Summary: Epigenomics play a role in cell identity and differentiation. We present the DNA methylation landscape of leukemic cells during in vitro differentiation, adding another omics layer to better understand differentiation mechanisms.
- Hormones as adaptive control systems in juvenile fish
Summary: We combine physiological, environmental and evolutionary aspects of fish growth in a state-dependent model where the optimal regulation of growth and survival is achieved through hormonal regulation of behaviour.
- Loss of Crb2b-lf leads to anterior segment defects in old zebrafish
Summary: Loss of the apico-basal polarity regulator Crb2b-lf does not affect retinal development but leads to ocular anterior segment defects in old zebrafish.
- Greb1 is required for axial elongation and segmentation in vertebrate embryos
Summary: The Greb1 transcriptional cofactor is expressed in the vertebrate tailbud and required for axial extension and segmentation of developing vertebrate embryos.
- The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components
Summary: In response to the change in the epithelial characteristics from esophagus to trachea/bronchus that happens when SOX2 is inactivated, surrounding mesenchymal tissues also change their characteristics accordingly at all axial levels.
- FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling
Summary: FAM172A inhibits EMT in pancreatic cancer via specifically regulating ERK-MAPK signaling.
- Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
Summary: An important steroidal saponin extracted from Rhizoma Paris, Polyphyllin II suppressed cell viability and induced cell apoptosis in liver cancer cells. Low doses of Polyphyllin II also inhibited liver cancer cell migration and invasion.
- Mechanical and molecular parameters that influence the tendon differentiation potential of C3H10T1/2 cells in 2D- and 3D-culture systems
Summary: Our results provide a better understanding of the culture conditions upon which we could act to trigger tendon cell differentiation from undifferentiated stem cells.
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New insights into how changes in epithelial structure can turn Notch nasty
To celebrate preLights’ second birthday, Sally Lowell wrote a guest preLight. A developmental and stem cell biologist at the MRC Centre for Regenerative Medicine at the University of Edinburgh, Sally is also one of the directors of The Company of Biologists.
Why publish in BiO?
Biology Open provides rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper for an easy and fast publication process. Recent cell biology highlights in BiO include work by Komori et al., which shows that IV-1 RNA translation may be enhanced through TAR RNA processing by TRBP in collaboration with Dicer, repressing host–cell apoptosis.
Meet this month’s first authors, James Fabrizio and Jaqueline Weidner. James discusses the implications of his results in relation to studying male infertility, while Jaqueline explains the difficulty of translating the complexity of human bodies into model development.
Cover article – Heart rate and cardiac response to exercise during voluntary dives in captive sea turtles (Cheloniidae)
On the cover of the latest issue - the endangered Green sea turtle. Okuyama et al. demonstrate that they show immediate cardiac response to exercise during submergence.