This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section.
RESEARCH ARTICLES
- Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4
Summary: Epigenomics play a role in cell identity and differentiation. We present the DNA methylation landscape of leukemic cells during in vitro differentiation, adding another omics layer to better understand differentiation mechanisms.
- Hormones as adaptive control systems in juvenile fish
Summary: We combine physiological, environmental and evolutionary aspects of fish growth in a state-dependent model where the optimal regulation of growth and survival is achieved through hormonal regulation of behaviour.
- Loss of Crb2b-lf leads to anterior segment defects in old zebrafish
Summary: Loss of the apico-basal polarity regulator Crb2b-lf does not affect retinal development but leads to ocular anterior segment defects in old zebrafish.
- Greb1 is required for axial elongation and segmentation in vertebrate embryos
Summary: The Greb1 transcriptional cofactor is expressed in the vertebrate tailbud and required for axial extension and segmentation of developing vertebrate embryos.
- The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components
Summary: In response to the change in the epithelial characteristics from esophagus to trachea/bronchus that happens when SOX2 is inactivated, surrounding mesenchymal tissues also change their characteristics accordingly at all axial levels.
- FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling
Summary: FAM172A inhibits EMT in pancreatic cancer via specifically regulating ERK-MAPK signaling.
- Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
Summary: An important steroidal saponin extracted from Rhizoma Paris, Polyphyllin II suppressed cell viability and induced cell apoptosis in liver cancer cells. Low doses of Polyphyllin II also inhibited liver cancer cell migration and invasion.
- Mechanical and molecular parameters that influence the tendon differentiation potential of C3H10T1/2 cells in 2D- and 3D-culture systems
Summary: Our results provide a better understanding of the culture conditions upon which we could act to trigger tendon cell differentiation from undifferentiated stem cells.
FIRST PERSON
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Why publish with BiO?
Biology Open provides rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper for an easy and fast publication process. Recent developmental biology highlights in in BiO include work by Teramoto et al., which looks at the change in epithelial characteristics in the anterior foregut in the absence of SOX2.
Hear from this month’s first authors: Setsuya Minami, Kate Quigley, Samantha Payne and Juan Garrido-Maraver talk about their papers and life as a researcher.
A study by Thomas Cansse and colleagues used bird-borne cameras on Australasian gannets in Bass Strait and found that animals foraging solitarily had lower levels of prey-capture success than animals foraging in groups. However, prey profitability was lower for group-foraging animals due to increased time expenditure to capture prey.