RESEARCH ARTICLES
- Tubulin-binding cofactor E-like (TBCEL), the protein product of the mulet gene, is required in the germline for the regulation of inter-flagellar microtubule dynamics during spermatid individualization
Summary: The leading cause of human male infertility is a failure to resolve spermatids from a germline syncytium during spermatid individualization. Here we characterize a mutation that disrupts this process.
- Heart rate and cardiac response to exercise during voluntary dives in captive sea turtles (Cheloniidae)
Summary: Green turtles showed immediate cardiac response to exercise during submergence, presumably because they store oxygen primarily in the lungs and need blood circulation to meet the metabolic demand.
- TRBP–Dicer interaction may enhance HIV-1 TAR RNA translation via TAR RNA processing, repressing host-cell apoptosis
Summary: HIV-1 RNA translation may be enhanced through TAR RNA processing by TRBP in collaboration with Dicer, repressing host–cell apoptosis.
- Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4
Summary: Epigenomics play a role in cell identity and differentiation. We present the DNA methylation landscape of leukemic cells during in vitro differentiation, adding another omics layer to better understand differentiation mechanisms.
- Hormones as adaptive control systems in juvenile fish
Summary: We combine physiological, environmental and evolutionary aspects of fish growth in a state-dependent model where the optimal regulation of growth and survival is achieved through hormonal regulation of behaviour.
- Loss of Crb2b-lf leads to anterior segment defects in old zebrafish
Summary: Loss of the apico-basal polarity regulator Crb2b-lf does not affect retinal development but leads to ocular anterior segment defects in old zebrafish.
- Greb1 is required for axial elongation and segmentation in vertebrate embryos
Summary: The Greb1 transcriptional cofactor is expressed in the vertebrate tailbud and required for axial extension and segmentation of developing vertebrate embryos.
- The absence of SOX2 in the anterior foregut alters the esophagus into trachea and bronchi in both epithelial and mesenchymal components
Summary: In response to the change in the epithelial characteristics from esophagus to trachea/bronchus that happens when SOX2 is inactivated, surrounding mesenchymal tissues also change their characteristics accordingly at all axial levels.
- FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling
Summary: FAM172A inhibits EMT in pancreatic cancer via specifically regulating ERK-MAPK signaling.
- Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
Summary: An important steroidal saponin extracted from Rhizoma Paris, Polyphyllin II suppressed cell viability and induced cell apoptosis in liver cancer cells. Low doses of Polyphyllin II also inhibited liver cancer cell migration and invasion.
- Mechanical and molecular parameters that influence the tendon differentiation potential of C3H10T1/2 cells in 2D- and 3D-culture systems
Summary: Our results provide a better understanding of the culture conditions upon which we could act to trigger tendon cell differentiation from undifferentiated stem cells.
This issue
Other journals from The Company of Biologists
Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Future Leader Review – early neurodegeneration of Alzheimer’s disease
A new Future Leader Review from Olayemi Olajide, Marcus Suvanto and Clifton Andrew Chapman evaluates the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
First author interviews
Catch up on our latest first author interviews to go behind the scenes of our latest research, find out more about the authors and hear from early-career researchers themselves how they’re finding life at the bench.
Retinal degeneration in Drosophila
Thank you to Elisabeth Knust and her team for their confocal image of a longitudinal section of an adult Drosophila retina, which brightens the cover of our latest issue. Read the research behind the cover.