EDITORIAL
RESEARCH ARTICLES
- Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy
Summary: Cellular mechanical damage is connected with the apoptosis of BMSCs, and the alterations in mechanics and nanomorphology could be used as a sensitive index to detect alterations in cell viability during apoptosis.
- Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin
Summary: This work provides evidence of a novel function for a blood fluke's glycolytic enzyme (GAPDH) activating plasmin to potentially degrade blood clots, thus aiding parasite survival in the host vasculature.
- Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states
Summary: High resolution traction force microscopy at single-cell level reveals the biophysical landscape of primary human myofibroblasts.
- The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila
Summary: We investigated the molecular mechanism of how sal/SALL4 regulates cell invasion and found that this process depends on the dMyc-JNK pathway.
- MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
Summary: This work illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy.
- Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
Summary: Ca2+ dysregulation in cardiomyocytes is a common feature of cardiomyopathy and heart failure pathogenesis. Here we demonstrate in Drosophila melanogaster that store-operated Ca2+ entry is essential for physiological heart function.
- MicroRNA-96-5p promotes proliferation, invasion and EMT of oral carcinoma cells by directly targeting FOXF2
Summary: Introduction of miR-96-5p promoted proliferation, invasion and EMT of OSCC cells by directly downregulating FOXF2 expression. Hence, these findings suggested important roles for miR-96-5p/FOXF2 axis in OSCC pathogenesis and its potential application in cancer therapy.
- Parametric generation of three-dimensional gait for robot-assisted rehabilitation
Summary: A method for the parametric generation of three-dimensional gait based on the influence of the motion parameters and structure parameters is presented.
- Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats
Summary: Sucrose consumption in liquid form predisposes rats to obesity, alters glycemic and lipid profiles, and impairs hepatic oxidative metabolism; hence, we caution against excessive consumption of artificially-sweetened beverages.
FIRST PERSON
This issue
Other journals from The Company of Biologists
Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Future Leader Review – early neurodegeneration of Alzheimer’s disease
A new Future Leader Review from Olayemi Olajide, Marcus Suvanto and Clifton Andrew Chapman evaluates the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
First author interviews
Catch up on our latest first author interviews to go behind the scenes of our latest research, find out more about the authors and hear from early-career researchers themselves how they’re finding life at the bench.
Retinal degeneration in Drosophila
Thank you to Elisabeth Knust and her team for their confocal image of a longitudinal section of an adult Drosophila retina, which brightens the cover of our latest issue. Read the research behind the cover.