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  Open access

March, 2020; 9 (3)

EDITORIAL

  • Open Access
    News from Biology Open in 2020
    Rachel Hackett (Managing Editor BiO)
    Biology Open 2020 9: bio051821 doi: 10.1242/bio.051821 Published 3 April 2020

RESEARCH ARTICLES

  • Open Access
    Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy
    Xuelian Su, Haijing Zhou, Guangjie Bao, Jizeng Wang, Lin Liu, Qian Zheng, Manli Guo, Jinting Zhang
    Biology Open 2020 9: bio048108 doi: 10.1242/bio.048108 Published 30 March 2020

    Summary: Cellular mechanical damage is connected with the apoptosis of BMSCs, and the alterations in mechanics and nanomorphology could be used as a sensitive index to detect alterations in cell viability during apoptosis.

  • Open Access
    Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin
    David B. Pirovich, Akram A. Da'dara, Patrick J. Skelly
    Biology Open 2020 9: bio050385 doi: 10.1242/bio.050385 Published 24 March 2020

    Summary: This work provides evidence of a novel function for a blood fluke's glycolytic enzyme (GAPDH) activating plasmin to potentially degrade blood clots, thus aiding parasite survival in the host vasculature.

  • Open Access
    Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states
    Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
    Biology Open 2020 9: bio049809 doi: 10.1242/bio.049809 Published 24 March 2020

    Summary: High resolution traction force microscopy at single-cell level reveals the biophysical landscape of primary human myofibroblasts.

  • Open Access
    The transcription factor Spalt and human homologue SALL4 induce cell invasion via the dMyc-JNK pathway in Drosophila
    Jie Sun, Junzheng Zhang, Dan Wang, Jie Shen
    Biology Open 2020 9: bio048850 doi: 10.1242/bio.048850 Published 24 March 2020

    Summary: We investigated the molecular mechanism of how sal/SALL4 regulates cell invasion and found that this process depends on the dMyc-JNK pathway.

  • Open Access
    MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
    Peihong Su, Chong Yin, Dijie Li, Chaofei Yang, Xue Wang, Jiawei Pei, Ye Tian, Airong Qian
    Biology Open 2020 9: bio048173 doi: 10.1242/bio.048173 Published 24 March 2020

    Summary: This work illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy.

  • Open Access
    Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
    Courtney E. Petersen, Matthew J. Wolf, Jeremy T. Smyth
    Biology Open 2020 9: bio049999 doi: 10.1242/bio.049999 Published 11 March 2020

    Summary: Ca2+ dysregulation in cardiomyocytes is a common feature of cardiomyopathy and heart failure pathogenesis. Here we demonstrate in Drosophila melanogaster that store-operated Ca2+ entry is essential for physiological heart function.

  • Open Access
    MicroRNA-96-5p promotes proliferation, invasion and EMT of oral carcinoma cells by directly targeting FOXF2
    Haiyan Wang, Ning Ma, Wenyue Li, Zuomin Wang
    Biology Open 2020 9: bio049478 doi: 10.1242/bio.049478 Published 11 March 2020

    Summary: Introduction of miR-96-5p promoted proliferation, invasion and EMT of OSCC cells by directly downregulating FOXF2 expression. Hence, these findings suggested important roles for miR-96-5p/FOXF2 axis in OSCC pathogenesis and its potential application in cancer therapy.

  • Open Access
    Parametric generation of three-dimensional gait for robot-assisted rehabilitation
    Di Shi, Wuxiang Zhang, Xilun Ding, Lei Sun
    Biology Open 2020 9: bio047332 doi: 10.1242/bio.047332 Published 5 March 2020

    Summary: A method for the parametric generation of three-dimensional gait based on the influence of the motion parameters and structure parameters is presented.

  • Open Access
    Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats
    Ellen Mayara Souza Cruz, Juliana Maria Bitencourt de Morais, Carlos Vinícius Dalto da Rosa, Mellina da Silva Simões, Jurandir Fernando Comar, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva
    Biology Open 2020 9: bio047282 doi: 10.1242/bio.047282 Published 28 February 2020

    Summary: Sucrose consumption in liquid form predisposes rats to obesity, alters glycemic and lipid profiles, and impairs hepatic oxidative metabolism; hence, we caution against excessive consumption of artificially-sweetened beverages.

FIRST PERSON

  • Open Access
    First person – David Pirovich
    Biology Open 2020 9: bio051631 doi: 10.1242/bio.051631 Published 24 March 2020
  • Open Access
    First person – Jie Sun
    Biology Open 2020 9: bio051144 doi: 10.1242/bio.051144 Published 24 March 2020
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
    PDF
  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
    PDF
  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
    PDF
  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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