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Research Article
Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Biology Open 2020 9: bio049809 doi: 10.1242/bio.049809 Published 24 March 2020
Thomas B. Layton
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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  • ORCID record for Thomas B. Layton
Lynn Williams
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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Huw Colin-York
2MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK
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  • ORCID record for Huw Colin-York
Fiona E. McCann
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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Marisa Cabrita
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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Marc Feldmann
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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Cameron Brown
3Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
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Weilin Xie
4Department of Inflammation Research, Celgene Corporation, San Diego, CA 92121, USA
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Marco Fritzsche
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
2MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK
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Dominic Furniss
3Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
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Jagdeep Nanchahal
1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
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  • For correspondence: jagdeep.nanchahal@kennedy.ox.ac.uk
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Article Information

vol. 9 no. 3, bio049809

DOI 
https://doi.org/10.1242/bio.049809
PubMed 
32139395

Published By 
The Company of Biologists Ltd
Online ISSN 
2046-6390
History 
  • Received December 2, 2019
  • Accepted February 21, 2020
  • Published online March 24, 2020.
Posted online 
March 05, 2020
Copyright & Usage 
© 2020. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (March 5, 2020 - 04:01).
  • You are viewing the most recent version of this article.

Author Information

  1. Thomas B. Layton1,
  2. Lynn Williams1,
  3. Huw Colin-York2,
  4. Fiona E. McCann1,
  5. Marisa Cabrita1,
  6. Marc Feldmann1,
  7. Cameron Brown3,
  8. Weilin Xie4,
  9. Marco Fritzsche1,2,
  10. Dominic Furniss3 and
  11. Jagdeep Nanchahal1,*
  1. 1The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
  2. 2MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford OX3 9DS, UK
  3. 3Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
  4. 4Department of Inflammation Research, Celgene Corporation, San Diego, CA 92121, USA
  1. ↵*Author for correspondence (jagdeep.nanchahal{at}kennedy.ox.ac.uk)

Article usage

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AbstractFullPdf
Mar 202042756129
Apr 202013222272
May 2020357034
Jun 2020194441
Jul 2020143027
Aug 2020142628
Sep 2020145429
Oct 2020105757
Nov 202033322
Dec 2020103524
Total 2020678627463
Jan 202144626
Feb 202173025
Mar 202183125
Total 20211910776
Total697734539

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Keywords

  • Focal adhesion
  • Myofibroblast
  • Single cell
  • Traction force

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Research Article
Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Biology Open 2020 9: bio049809 doi: 10.1242/bio.049809 Published 24 March 2020
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Research Article
Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Biology Open 2020 9: bio049809 doi: 10.1242/bio.049809 Published 24 March 2020

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