RESEARCH ARTICLES
- Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice
Summary: Vascular non-inflammatory molecule 1 (vannin-1) is elevated in intrauterine growth retardation (IUGR) asthmatic mice, leading to activation of the PI3K/Akt/NFκB pathway responsible for bronchial oxidative stress and hyperresponsiveness.
- Evolutionary insights in Amazonian turtles (Testudines, Podocnemididae): co-location of 5S rDNA and U2 snRNA and wide distribution of Tc1/Mariner
Summary: This paper is important for understanding karyotype evolutionary dynamics in Amazonian turtles, focusing on physical mapping of repetitive DNA sequences.
- Coupled regulations of enzymatic activity and structure formation of aldehyde dehydrogenase Ald4p
Summary: A mutation study of cytoplasmically targeted aldehyde dehydrogenase Ald4p was conducted to show that the Ald4p structure formation is coupled to the regulation of its enzymatic activity.
- Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies
Summary: Nucleolar stress (loss of ribosome production/function) in certain human progenitor or stem cells results in disease. In fruit flies, larval mushroom body neuroblasts are relatively resilient to nucleolar stress.
- Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish
Summary: By coupling human medical genetics and in vivo functional analysis we show that GABRA1 regulates motility and the expression of specific subunits of the GABAA receptor during zebrafish development.
- Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing
Summary: The cerebellum was believed to have no role in controlling eupneic respiration. Our findings suggest a cerebellar involvement in the coordination of breathing with other orofacial movements, such as swallowing.
- Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)
Summary: We investigated the effects of starvation on sex differentiation in medaka. Starvation caused female-to-male sex reversal through pantothenate metabolism, fatty acid synthesis and dmrt1 expression.
- A topological analysis of difference topology experiments of condensin with topoisomerase II
Summary: Tangles are used to model protein-DNA complexes. A three-dimensional ball represents protein while strings embedded in this ball represent protein-bound DNA. We used this simple model to analyze experimental results.
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Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Future Leader Review – early neurodegeneration of Alzheimer’s disease
A new Future Leader Review from Olayemi Olajide, Marcus Suvanto and Clifton Andrew Chapman evaluates the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
First author interviews
Catch up on our latest first author interviews to go behind the scenes of our latest research, find out more about the authors and hear from early-career researchers themselves how they’re finding life at the bench.
Retinal degeneration in Drosophila
Thank you to Elisabeth Knust and her team for their confocal image of a longitudinal section of an adult Drosophila retina, which brightens the cover of our latest issue. Read the research behind the cover.