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  You have access

  Open access

April, 2020; 9 (4)

RESEARCH ARTICLES

  • Open Access
    Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice
    Yan Xing, Hongling Wei, Xiumei Xiao, Zekun Chen, Hui Liu, Xiaomei Tong, Wei Zhou
    Biology Open 2020 9: bio049106 doi: 10.1242/bio.049106 Published 28 April 2020

    Summary: Vascular non-inflammatory molecule 1 (vannin-1) is elevated in intrauterine growth retardation (IUGR) asthmatic mice, leading to activation of the PI3K/Akt/NFκB pathway responsible for bronchial oxidative stress and hyperresponsiveness.

  • Open Access
    Evolutionary insights in Amazonian turtles (Testudines, Podocnemididae): co-location of 5S rDNA and U2 snRNA and wide distribution of Tc1/Mariner
    Manoella Gemaque Cavalcante, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, Renata Coelho Rodrigues Noronha
    Biology Open 2020 9: bio049817 doi: 10.1242/bio.049817 Published 28 April 2020

    Summary: This paper is important for understanding karyotype evolutionary dynamics in Amazonian turtles, focusing on physical mapping of repetitive DNA sequences.

  • Open Access
    Coupled regulations of enzymatic activity and structure formation of aldehyde dehydrogenase Ald4p
    Chalongrat Noree, Naraporn Sirinonthanawech
    Biology Open 2020 9: bio051110 doi: 10.1242/bio.051110 Published 28 April 2020

    Summary: A mutation study of cytoplasmically targeted aldehyde dehydrogenase Ald4p was conducted to show that the Ald4p structure formation is coupled to the regulation of its enzymatic activity.

  • Open Access
    Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies
    Sonu Shrestha Baral, Molly E. Lieux, Patrick J. DiMario
    Biology Open 2020 9: bio046565 doi: 10.1242/bio.046565 Published 13 April 2020

    Summary: Nucleolar stress (loss of ribosome production/function) in certain human progenitor or stem cells results in disease. In fruit flies, larval mushroom body neuroblasts are relatively resilient to nucleolar stress.

  • Open Access
    Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish
    Nayeli G. Reyes-Nava, Hung-Chun Yu, Curtis R. Coughlin II, Tamim H. Shaikh, Anita M. Quintana
    Biology Open 2020 9: bio051367 doi: 10.1242/bio.051367 Published 13 April 2020

    Summary: By coupling human medical genetics and in vivo functional analysis we show that GABRA1 regulates motility and the expression of specific subunits of the GABAA receptor during zebrafish development.

  • Open Access
    Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing
    Yu Liu, Shuhua Qi, Fridtjof Thomas, Brittany L. Correia, Angela P. Taylor, Roy V. Sillitoe, Detlef H. Heck
    Biology Open 2020 9: bio048785 doi: 10.1242/bio.048785 Published 13 April 2020

    Summary: The cerebellum was believed to have no role in controlling eupneic respiration. Our findings suggest a cerebellar involvement in the coordination of breathing with other orofacial movements, such as swallowing.

  • Open Access
    Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)
    Yuta Sakae, Akira Oikawa, Yuki Sugiura, Masatoshi Mita, Shuhei Nakamura, Toshiya Nishimura, Makoto Suematsu, Minoru Tanaka
    Biology Open 2020 9: bio050054 doi: 10.1242/bio.050054 Published 7 April 2020

    Summary: We investigated the effects of starvation on sex differentiation in medaka. Starvation caused female-to-male sex reversal through pantothenate metabolism, fatty acid synthesis and dmrt1 expression.

  • Open Access
    A topological analysis of difference topology experiments of condensin with topoisomerase II
    Soojeong Kim, Isabel K. Darcy
    Biology Open 2020 9: bio048603 doi: 10.1242/bio.048603 Published 3 April 2020

    Summary: Tangles are used to model protein-DNA complexes. A three-dimensional ball represents protein while strings embedded in this ball represent protein-bound DNA. We used this simple model to analyze experimental results.

FIRST PERSON

  • Open Access
    First person – Sonu S. Baral
    Biology Open 2020 9: bio052167 doi: 10.1242/bio.052167 Published 13 April 2020
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
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  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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