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  You have access

  Open access

June, 2020; 9 (6)

RESEARCH ARTICLES

  • Open Access
    The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain
    Stéphanie Cottier, Rabih Darwiche, Felix Meyenhofer, Mykhaylo O. Debelyy, Roger Schneiter
    Biology Open 2020 9: bio053470 doi: 10.1242/bio.053470 Published 2 July 2020

    Summary: Overexpression of Pry3, a GPI-anchored cell wall protein inhibits the yeast mating reaction. Here we show that this mating inhibition depends on highly conserved residues within the CAP/SCP/TAPS domain of Pry3.

  • Open Access
    Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway
    Jaroslav Fabik, Katarina Kovacova, Zbynek Kozmik, Ondrej Machon
    Biology Open 2020 9: bio052043 doi: 10.1242/bio.052043 Published 2 July 2020

    Summary: Wnt1-Cre2;Meis2fl/fl mutants have perturbed Shh activity in the oral region of the mandibular arch, which leads to specification failure of NCCs in the tongue primordium and ectopic ossification at the expense of glossogenesis, which are hallmarks of several mouse mutants with eliminated Shh activity.

  • Open Access
    Overexpression of Wnt7a enhances radiosensitivity of non-small-cell lung cancer via the Wnt/JNK pathway
    Pingping Ai, Xianhua Xu, Shijie Xu, Zhixia Wei, Shun Tan, Junzhe Li
    Biology Open 2020 9: bio050575 doi: 10.1242/bio.050575 Published 27 June 2020

    Summary: The radiosensitizing effect of Wnt7a in non-small-cell lung cancer (NSCLC).

  • Open Access
    Microtubule assembly and pole coalescence: early steps in Caenorhabditis elegans oocyte meiosis I spindle assembly
    Chien-Hui Chuang, Aleesa J. Schlientz, Jie Yang, Bruce Bowerman
    Biology Open 2020 9: bio052308 doi: 10.1242/bio.052308 Published 25 June 2020

    Summary: This paper documents requirements for several regulators of microtubule assembly and stability during the early steps of acentrosomal meiotic spindle assembly in Caenorhabditis elegans oocytes.

  • Open Access
    lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p
    Ting Xiao, Chuihua Sun, Ying Xiao, Yunbao Li
    Biology Open 2020 9: bio049353 doi: 10.1242/bio.049353 Published 24 June 2020

    Summary: Knockdown of NEAT1 hampered sepsis progression by downregulating Irak2 via interacting with miR-370-3p in LPS-induced RAW 264.7 and HL-1 cells.

  • Open Access
    Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis
    Jessica Sam, Emily J. Mercer, Ingrid Torregroza, Kelly M. Banks, Todd Evans
    Biology Open 2020 9: bio053611 doi: 10.1242/bio.053611 Published 24 June 2020

    Summary: Targeted mutations were generated for each of the three gata4/5/6 genes in zebrafish to define functions for individual or combinations of these related transcription factors during cardiogenesis.

  • Open Access
    Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages
    Maya Morita, Mayu Kajiye, Chiye Sakurai, Shuichi Kubo, Miki Takahashi, Daiki Kinoshita, Naohiro Hori, Kiyotaka Hatsuzawa
    Biology Open 2020 9: bio051029 doi: 10.1242/bio.051029 Published 23 June 2020

    Summary: MORN2, whose stability is regulated by the ubiquitin-proteasome system, functions as a limiting factor for LAP via the regulation of SNAP-23 membrane trafficking for ROS production within macrophage phagosomes.

  • Open Access
    Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations
    Debabrata Patra, Joongho Kim, Qiang Zhang, Eric Tycksen, Linda J. Sandell
    Biology Open 2020 9: bio052993 doi: 10.1242/bio.052993 Published 23 June 2020

    Summary: Ablation of S1P in the osterix-lineage downregulates bone development due to hematopoietic progenitor alterations that increase bone marrow neutrophils with accompanying increases in stefin proteins with osteogenic inhibitory activity.

  • Open Access
    Bumblebees land remarkably well in red–blue greenhouse LED light conditions
    Lana J. de Vries, Frank van Langevelde, Coby van Dooremalen, Ilse G. Kornegoor, Martin J. Lankheet, Johan L. van Leeuwen, Marc Naguib, Florian T. Muijres
    Biology Open 2020 9: bio046730 doi: 10.1242/bio.046730 Published 11 June 2020

    Summary: Red–blue LED lights are being used in greenhouses to improve plant growth. The changed light spectrum may affect pollinators. We studied how these lights affect landing performance of foraging bumblebees.

  • Open Access
    A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression
    Shan Liu, Antje K. Biesemeier, Alexander V. Tschulakow, Harsh V. Thakkar, Sylvie Julien-Schraermeyer, Ulrich Schraermeyer
    Biology Open 2020 9: bio048736 doi: 10.1242/bio.048736 Published 11 June 2020

    Summary: We developed a new treatment-naive quiescent rat choroidal neovascularization model by VEGF overexpression, allowing the long-term investigation of new drugs.

  • Open Access
    Lizard colour plasticity tracks background seasonal changes
    Daniele Pellitteri-Rosa, Andrea Gazzola, Simone Todisco, Fabio Mastropasqua, Cristiano Liuzzi
    Biology Open 2020 9: bio052415 doi: 10.1242/bio.052415 Published 4 June 2020

    Summary: Our study shows seasonal variation in lizard dorsal colour as a potential adaptive trait in response to environmental background change, and highlights the importance of collecting colour data throughout the year.

METHODS & TECHNIQUES

  • Open Access
    A machine vision system for tracking population behavior of zooplankton in small-scale experiments: a case study on salmon lice (Lepeophtheirus salmonis Krøyer, 1838) copepodite population responses to different light stimuli
    Bjarne Kvæstad, Trond Nordtug, Andreas Hagemann
    Biology Open 2020 9: bio050724 doi: 10.1242/bio.050724 Published 25 June 2020

    Summary: A suggested method for tracking large populations (n=200) of small (<1 mm length) zooplankton for behavior study when exposed to stimuli.

  • Open Access
    Model selection versus traditional hypothesis testing in circular statistics: a simulation study
    Lukas Landler, Graeme D. Ruxton, E. Pascal Malkemper
    Biology Open 2020 9: bio049866 doi: 10.1242/bio.049866 Published 23 June 2020

    Summary: Model selection-based statistics is a promising new avenue for analyzing circular data. We describe a procedure to control the type I error rate.

  • Open Access
    A fully automated deep learning pipeline for high-throughput colony segmentation and classification
    Sarah H. Carl, Lea Duempelmann, Yukiko Shimada, Marc Bühler
    Biology Open 2020 9: bio052936 doi: 10.1242/bio.052936 Published 23 June 2020

    Summary: We have developed a computational pipeline, using neural networks, which enables automated high-throughput adenine auxotrophy-based screening and quantification. Our pipeline speeds up white/red color quantification by 100-fold with very high accuracy and can be smoothly integrated into existing protocols.

  • Open Access
    A gum Arabic assisted sustainable drug delivery system for adult Drosophila
    Qiying Liang, Peng Ma, Qi Zhang, Youjie Yin, Ping Wang, Saifei Wang, Yao Zhang, Ruolei Han, Hansong Deng
    Biology Open 2020 9: bio052241 doi: 10.1242/bio.052241 Published 14 June 2020

    Summary: Drug insolubility and a lack of a continuous delivery system are big challenges for large-scale compound screenings in flies. The authors developed a U-GLAD system that can successfully solve these issues.

FIRST PERSON

  • Open Access
    First person – Stéphanie Cottier
    Biology Open 2020 9: bio054171 doi: 10.1242/bio.054171 Published 2 July 2020
  • Open Access
    First person – Jessica Sam
    Biology Open 2020 9: bio054247 doi: 10.1242/bio.054247 Published 24 June 2020
  • Open Access
    First person – Lana de Vries
    Biology Open 2020 9: bio053413 doi: 10.1242/bio.053413 Published 23 June 2020
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  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
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  • Open Access

    Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry

    Hantian Qiu, Sayaka Fujisawa, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama
    PDF
  • Open Access

    A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference

    Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye
    PDF
  • Open Access

    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling

    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
    PDF
  • Open Access

    Wound-induced polyploidization is dependent on integrin-yki signaling

    Rose Besen-McNally, Kayla J. Gjelsvik, Vicki P. Losick
    PDF
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