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  You have access

  Open access

July, 2020; 9 (7)

RESEARCH ARTICLES

  • Open Access
    Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms
    Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way, Carolyn A. Moores
    Biology Open 2020 9: bio054304 doi: 10.1242/bio.054304 Published 31 July 2020

    Summary: The Arp2/3 complex stimulates formation of branched actin filament networks and exhibits isoform diversity in mammals. We show how different Arp2/3 subunit isoforms contribute to differences in complex function.

  • Open Access
    Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis
    Zhe Zhang, Dhanisha Jhaveri, Sazia Sharmin, Tracey J. Harvey, Paul A. Dawson, Michael Piper, David G. Simmons
    Biology Open 2020 9: bio053132 doi: 10.1242/bio.053132 Published 31 July 2020

    Summary Statement: Heterozygosity for the brain sulfate transporter Slc13a4 during postnatal development results in life-long abnormal hippocampal neurogenesis.

  • Open Access
    HSP70 drives myoblast fusion during C2C12 myogenic differentiation
    Savant S. Thakur, Kristy Swiderski, Victoria L. Chhen, Janine L. James, Nicki J. Cranna, A. M. Taufiqual Islam, James G. Ryall, Gordon S. Lynch
    Biology Open 2020 9: bio053918 doi: 10.1242/bio.053918 Published 22 July 2020

    Summary: In C2C12 myoblasts, HSP70 overexpression does not alter proliferation or differentiation but enhances fusion to increase myotube size.

  • Open Access
    The effects of temperature on the proxies of visual detection of Danio rerio larvae: observations from the optic tectum
    Ewa Babkiewicz, Michał Bazała, Paulina Urban, Piotr Maszczyk, Magdalena Markowska, Z. Maciej Gliwicz
    Biology Open 2020 9: bio047779 doi: 10.1242/bio.047779 Published 21 July 2020

    Summary: During the assessment of the visual detection distance of transgenic Danio rerio larvae in response to a visual stimulus using selective plane illumination microscopy, we found that the distance is shorter at elevated temperatures.

  • Open Access
    CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production
    Jacqueline C. Simonet, Maya J. Foster, Eric M. Lynch, Justin M. Kollman, Emmanuelle Nicholas, Alana M. O'Reilly, Jeffrey R. Peterson
    Biology Open 2020 9: bio050328 doi: 10.1242/bio.050328 Published 21 July 2020

    Summary: A point mutation in the nucleotide biosynthetic enzyme CTP synthase dominantly inhibits its polymerization and can be used to suppress CTPS assembly in a tissue-specific manner in vivo. Disrupting assembly in ovarian germline cells reduces egg production, demonstrating a functional role for CTPS assembly.

  • Open Access
    Mechanical and energetic determinants of impaired gait following stroke: segmental work and pendular energy transduction during treadmill walking
    Gustavo Balbinot, Clarissa Pedrini Schuch, Henrique Bianchi Oliveira, Leonardo A. Peyré-Tartaruga
    Biology Open 2020 9: bio051581 doi: 10.1242/bio.051581 Published 21 July 2020

    Summary: Walking after a stroke may be energetically consuming. Here, we show how compensations and asymmetries may contribute to increasing the amount of work needed to walk following a stroke.

  • Open Access
    Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe
    Agamani Ghosal, Priyanka Sarkar, Geetanjali Sundaram
    Biology Open 2020 9: bio053322 doi: 10.1242/bio.053322 Published 21 July 2020

    Summary: Modulation of Cdc2 activity can change the extent of Spc1 activation and preserve mitotic fidelity in Schizosaccharomyces pombe cells.

  • Open Access
    Phospholipids containing ether-bound hydrocarbon-chains are essential for efficient phagocytosis and neutral lipids of the ester-type perturb development in Dictyostelium
    Frederik Kappelt, Xiaoli Du Ma, Bassam Abou Hasna, Jessica M. Kornke, Markus Maniak
    Biology Open 2020 9: bio052126 doi: 10.1242/bio.052126 Published 16 July 2020

    Summary: Lean Dictyostelium mutants that fail to produce storage fat, survive starvation and succeed in spore formation, whereas cell strains impaired in ether-type membrane lipid production are perturbed in phagocytosis.

  • Open Access
    Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells
    Elisabeth Nüske, Guendalina Marini, Doris Richter, Weihua Leng, Aliona Bogdanova, Titus M. Franzmann, Gaia Pigino, Simon Alberti
    Biology Open 2020 9: bio046391 doi: 10.1242/bio.046391 Published 8 July 2020

    Summary: Filament formation by eIF2B is an adaptive mechanism that allows for efficient shutdown of translation in starved yeast cells.

  • Open Access
    Responses to transient receptor potential (TRP) channel agonists in Chlamydomonas reinhardtii
    Mamoru Wada, Itaru Kaizuka, Kenjiro Yoshimura
    Biology Open 2020 9: bio053140 doi: 10.1242/bio.053140 Published 8 July 2020

    Summary: Chlamydomonas reinhardtii cells lose motility and excise flagella upon application of pungent TRP channel agonists such as capsaicin and gingerol, likely through TRP channel activity, including ADF1.

  • Open Access
    Downregulated brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 inhibits osteogenesis of BMSCs through p53 in type 2 diabetes mellitus
    Xiaofei Mao, Xiaoguang Li, Wei Hu, Siwei Hao, Yifang Yuan, Lian Guan, Bin Guo
    Biology Open 2020 9: bio051482 doi: 10.1242/bio.051482 Published 8 July 2020

    Summary: This article reported for the first time that inhibition of BMSCs osteogenic differentiation by downregulated BMAL1 in T2DM was mediated by p53.

  • Open Access
    Brain-encysting trematodes (Euhaplorchis californiensis) decrease raphe serotonergic activity in California killifish (Fundulus parvipinnis)
    Siri H. Helland-Riise, Marco A. Vindas, Ida B. Johansen, Lauren E. Nadler, Kelly L. Weinersmith, Ryan F. Hechinger, Øyvind Øverli
    Biology Open 2020 9: bio049551 doi: 10.1242/bio.049551 Published 8 July 2020

    Summary: Post-stress 5-HT signalling decrease with parasite density in killifish infected with brain-dwelling Euhaplorchis californiensis metacercariae, in a manner consistent with decreased impulse control and increased risk taking in infected fish.

METHODS & TECHNIQUES

  • Open Access
    Going beyond conventional parameters to unveil sperm quality in fish: the use of fibre optic technology to assess mitochondrial respiratory performance
    Lisa Locatello, Giovanni Rigoni, Maria E. Soriano, Maria B. Rasotto, Federica Poli
    Biology Open 2020 9: bio053306 doi: 10.1242/bio.053306 Published 31 July 2020

    Summary: A novel technique to measure sperm mitochondrial respiratory efficiency, an overlooked parameter of sperm quality that might contribute in unveiling mechanisms driving the intraspecific variability in sperm performance.

FIRST PERSON

  • Open Access
    First person – Jacqueline Simonet
    Biology Open 2020 9: bio054718 doi: 10.1242/bio.054718 Published 27 August 2020
  • Open Access
    First Person - Gustavo Balbinot and Clarissa Pedrini Schuch
    Biology Open 2020 9: bio054403 doi: 10.1242/bio.054403 Published 6 August 2020
  • Open Access
    First person – Savant Thakur
    Biology Open 2020 9: bio054593 doi: 10.1242/bio.054593 Published 24 July 2020
  • Open Access
    First person – Agamani Ghosal
    Biology Open 2020 9: bio054163 doi: 10.1242/bio.054163 Published 21 July 2020
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  • Open Access

    Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype

    Xinhong Liu, Yu-Gang Li, Fang Tan, Jia Liu, Ruokun Yi, Xin Zhao
    PDF
  • Open Access

    Oviductal fluid counterbalances the negative effect of high temperature on sperm in an ectotherm model

    N. Rossi, G. Lopez Juri, M. Chiaraviglio, G. Cardozo
    PDF
  • Open Access

    High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

    Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
    PDF
  • Open Access

    Overexpression of long non-coding RNA SBF2-AS1 promotes cell progression in esophageal squamous cell carcinoma (ESCC) by repressing miR-494 to up-regulate PFN2 expression

    Qiu Zhang, Xixiang Pan, Dongyang You
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