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  Open access

August, 2020; 9 (8)

REVIEW

  • Open Access
    Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system
    Eugene Jennifer Jin, Seungmee Park, Xiaohui Lyu, Yishi Jin
    Biology Open 2020 9: bio053983 doi: 10.1242/bio.053983 Published 3 September 2020

    Summary: Studies from C. elegans have illustrated many roles of gap junctions in neural connectivity and circuit regulation, during normal conditions and under stress.

RESEARCH ARTICLES

  • Open Access
    Effect of serotonin modulation on dystrophin-deficient zebrafish
    Janelle M. Spinazzola, Matthias R. Lambert, Devin E. Gibbs, James R. Conner, Georgia L. Krikorian, Prithu Pareek, Carlo Rago, Louis M. Kunkel
    Biology Open 2020 9: bio053363 doi: 10.1242/bio.053363 Published 28 August 2020

    Summary: Phenotypic screening of serotonin pathway modulators has been performed in DMD zebrafish in order to identify small-molecules that limit the dystrophic muscle phenotype and lengthen the lifespan as potential therapeutics.

  • Open Access
    Functionally distinct roles for T and Tbx6 during mouse development
    Amy K. Wehn, Deborah R. Farkas, Carly E. Sedlock, Dibya Subedi, Deborah L. Chapman
    Biology Open 2020 9: bio054692 doi: 10.1242/bio.054692 Published 27 August 2020

    Summary: Mouse Tbx6 fails to compensate for heterozygous loss of T; instead ectopic Tbx6 in the T expression-domain in knockin embryos generates T null-like phenotypes suggestive of competition.

  • Open Access
    Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density
    Prajal H. Patel, Emily C. Wilkinson, Emily L. Starke, Malea R. McGimsey, J. Todd Blankenship, Scott A. Barbee
    Biology Open 2020 9: bio053421 doi: 10.1242/bio.053421 Published 25 August 2020

    Summary: The retrograde vesicle tethering factor, Vps54, regulates development of the Drosophila larval NMJ. Moreover, presynaptic Vps54 interacts genetically with the small GTPase, Rab7, to control NMJ growth and postsynaptic density composition.

  • Open Access
    Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells
    Barbara Dhooghe, Caroline Bouzin, Angélique Mottais, Emmanuel Hermans, Martial Delion, Nadtha Panin, Sabrina Noel, Teresinha Leal
    Biology Open 2020 9: bio053116 doi: 10.1242/bio.053116 Published 25 August 2020

    Summary: Our findings support the view that vardenafil, a phosphodiesterase type 5 inhibitor, partially rescues F508del protein through cGMP/PKG-independent mechanisms in cystic fibrosis cell line.

  • Open Access
    Compartment and cell-type specific hypoxia responses in the developing Drosophila brain
    Martin Baccino-Calace, Daniel Prieto, Rafael Cantera, Boris Egger
    Biology Open 2020 9: bio053629 doi: 10.1242/bio.053629 Published 18 August 2020

    Summary: A fluorescent biosensor reveals cell type specific hypoxia levels in the Drosophila brain in unprecedented detail. It paves the way for further functional studies addressing the role of oxygen in neural stem cell maintenance and differentiation.

  • Open Access
    Water transport mediated by murine urea transporters: implications for urine concentration mechanisms
    J. Kabutomori, N. Pina-Lopes, R. Musa-Aziz
    Biology Open 2020 9: bio051805 doi: 10.1242/bio.051805 Published 14 August 2020

    Summary: Renal urea transporters can transport both urea and water, which could have direct effects on renal function, especially the production of concentrated urine.

  • Open Access
    The protective effects of human milk-derived peptides on the pancreatic islet biology
    Amitoj Singh, Ashwantha Kumar Enjapoori, Yann Gibert, Karen M. Dwyer
    Biology Open 2020 9: bio049304 doi: 10.1242/bio.049304 Published 14 August 2020

    Summary: Human mild contains bioactive peptides – β-casomorphins (BCM) – that influence β-cell biology. Specifically human BCM increased the insulin domain of expression in zebrafish embryos and did not interfere with β-cell regeneration. This may have relevance for breastfeeding practices.

  • Open Access
    Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes
    Lisa te Molder, Liesbeth Hoekman, Maaike Kreft, Onno Bleijerveld, Arnoud Sonnenberg
    Biology Open 2020 9: bio054155 doi: 10.1242/bio.054155 Published 13 August 2020

    Summary: Comparative interactomics analysis reveals close proximity of HDs, FAs and CMSCs, and a role of CD151 in linking α3β1 and α6β4 together in an alternative type II HD-like adhesion complex.

FIRST PERSON

  • Open Access
    First person to Watch – E. Jennifer Jin, Seungmee Park and Xiaohui Lyu
    Biology Open 2020 9: bio055780 doi: 10.1242/bio.055780 Published 3 September 2020
  • Open Access
    First person – Martín Baccino-Calace
    Biology Open 2020 9: bio055483 doi: 10.1242/bio.055483 Published 18 August 2020
  • Open Access
    First person – Jessica Kabutomori
    Biology Open 2020 9: bio054981 doi: 10.1242/bio.054981 Published 14 August 2020
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
    PDF
  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
    PDF
  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
    PDF
  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
    PDF
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