This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section.
RESEARCH ARTICLES
- Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster
Summary: We show that fruit flies with shortened sleep patterns have decreased aging rates and increased longevity, while flies with disrupted circadian rhythm have decreased longevity. Our data suggests that circadian and sleep systems interact differentially with mechanisms of aging.
- STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations
Summary: By using naturally-occurring mutations in a human disease, we demonstrate the critical role of endogenous STAT3 in modulating reprogramming efficiency in human somatic cells.
- Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
Summary: In this study, we developed a tamoxifen-inducible transgenic mouse model that closely mimics the age-related onset of pancreatic cancer (PC). We showed that activation of Kras (iKC) specifically regulates transcription factors that promote mucin expression and acinar to ductal metaplasia, whereas, loss of KrasG12D allele in PC cells resulted in the reduction of mucin proteins such as MUC1, MUC4, MUC5AC and MUC16.
- Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells
Summary: Our research is the first report of developing sensor probes to detect activated-CAPN3 in cultured skeletal muscle cells.
- Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.
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Biology Open and COVID-19
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It’s a time of turmoil for young scientists
“My students are my priority – they are on the brink of their careers.”
Dr Jodie Rummer (ARC Centre of Excellence for Coral Reef Studies at James Cook University) talks about the importance of her role as a supervisor in supporting graduate students and post docs financially, intellectually and emotionally during this period of uncertainty.
Gap junctions: historical discoveries and new findings in the C. elegans nervous system
Following the announcement of Biology Open’s new Future Leader Review articles, we are thrilled to publish our first one! Jin, Park, Lyu et al. highlight the diverse roles of gap junctions and innexins in the C. elegans nervous system, contributing to fundamental understanding of gap junctions in all animals.
Interview - Jessica Kabutomori
First author Jessica Kabutomori talks about her latest paper in BiO, which investigates murine urea transporters, sharing the biggest surprise of her work and what she has planned for the future.