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  You have access

  Open access

September, 2020; 9 (9)

RESEARCH ARTICLES

  • Open Access
    Inhibition of ER stress improves progressive motor deficits in a REEP1-null mouse model of hereditary spastic paraplegia
    Bingjie Wang, You Yu, Lai Wei, Yan Zhang
    Biology Open 2020 9: bio054296 doi: 10.1242/bio.054296 Published 29 September 2020

    Summary: Endoplasmic reticulum (ER) stress plays an important role in hereditary spastic paraplegias (HSPs) pathology, providing new opportunities for HSP treatment.

  • Open Access
    Cell-to-cell communication mediates glioblastoma progression in Drosophila
    Marta Portela, Teresa Mitchell, Sergio Casas-Tintó
    Biology Open 2020 9: bio053405 doi: 10.1242/bio.053405 Published 29 September 2020

    Summary: Using a Drosophila model of glioblastoma (GB), we describe the temporal organisation of the main cellular events that occur in GB, including cell-to-cell interactions, neurodegeneration and tumour microtubes expansion.

  • Open Access
    Effects of short-term fasting on spontaneous activity and excess post-exercise oxygen consumption in four juvenile fish species with different foraging strategies
    Xiuming Li, Yaoguang Zhang, Shijian Fu
    Biology Open 2020 9: bio051755 doi: 10.1242/bio.051755 Published 29 September 2020

    Summary: This study compares the spontaneous behavior and exhaustive exercise of four warm-water fish.

  • Open Access
    Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules
    Edward F. Boumil, Rishel B. Vohnoutka, Sangmook Lee, Thomas B. Shea
    Biology Open 2020 9: bio052530 doi: 10.1242/bio.052530 Published 25 September 2020

    Summary: Tau inhibits axonal transport by blocking kinesin translocation or as kinesin cargo. Tau capable and incapable of microtubule binding inhibited transport equally, indicating inhibition of axonal transport as kinesin cargo.

  • Open Access
    Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors
    Tiyasha Sarkar, Nisha Patro, Ishan Kumar Patro
    Biology Open 2020 9: bio054130 doi: 10.1242/bio.054130 Published 24 September 2020

    Summary: This study is the first of its kind that practically investigated the combined exposure of major early life stressors like protein malnourishment and viral and bacterial infections on the nervous system.

  • Open Access
    Cardiac hypertrophy in a dish: a human stem cell based model
    Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren
    Biology Open 2020 9: bio052381 doi: 10.1242/bio.052381 Published 21 September 2020

    Summary: This research describes a functional in vitro model of cardiac hypertrophy, and how the time of stimulation with endothelin-1 affects the cells.

  • Open Access
    Visual signal evolution along complementary color axes in four bird lineages
    Anand Krishnan, Avehi Singh, Krishnapriya Tamma
    Biology Open 2020 9: bio052316 doi: 10.1242/bio.052316 Published 18 September 2020

    Summary: In four diverse bird radiations, we reveal the presence of complementary colors, putatively for higher contrast. Color patterns may have diversified by redistributing a complementary color pair over the body.

  • Open Access
    Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster
    Jacqueline B. Thompson, Oanh Oanh Su, Nou Yang, Johannes H. Bauer
    Biology Open 2020 9: bio054361 doi: 10.1242/bio.054361 Published 16 September 2020

    Summary: We show that fruit flies with shortened sleep patterns have decreased aging rates and increased longevity, while flies with disrupted circadian rhythm have decreased longevity. Our data suggests that circadian and sleep systems interact differentially with mechanisms of aging.

  • Open Access
    STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations
    Zhen Yu, Natalia I. Dmitrieva, Avram D. Walts, Hui Jin, Yangtengyu Liu, Xianfeng Ping, Elisa A. Ferrante, Lugui Qiu, Steven M. Holland, Alexandra F. Freeman, Guibin Chen, Manfred Boehm
    Biology Open 2020 9: bio052662 doi: 10.1242/bio.052662 Published 10 September 2020

    Summary: By using naturally-occurring mutations in a human disease, we demonstrate the critical role of endogenous STAT3 in modulating reprogramming efficiency in human somatic cells.

  • Open Access
    Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
    Kavita Mallya, Dhanya Haridas, Parthasarathy Seshacharyulu, Ramesh Pothuraju, Wade M. Junker, Shiv Ram Krishn, Sakthivel Muniyan, Raghupathy Vengoji, Surinder K. Batra, Satyanarayana Rachagani
    Biology Open 2020 9: bio052878 doi: 10.1242/bio.052878 Published 7 September 2020

    Summary: In this study, we developed a tamoxifen-inducible transgenic mouse model that closely mimics the age-related onset of pancreatic cancer (PC). We showed that activation of Kras (iKC) specifically regulates transcription factors that promote mucin expression and acinar to ductal metaplasia, whereas, loss of KrasG12D allele in PC cells resulted in the reduction of mucin proteins such as MUC1, MUC4, MUC5AC and MUC16.

  • Open Access
    Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells
    Koichi Ojima, Shoji Hata, Fumiko Shinkai-Ouchi, Mika Oe, Susumu Muroya, Hiroyuki Sorimachi, Yasuko Ono
    Biology Open 2020 9: bio048975 doi: 10.1242/bio.048975 Published 4 September 2020

    Summary: Our research is the first report of developing sensor probes to detect activated-CAPN3 in cultured skeletal muscle cells.

  • Open Access
    Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
    Komal Panchal, Anand Krishna Tiwari
    Biology Open 2020 9: bio049569 doi: 10.1242/bio.049569 Published 3 September 2020

    Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.

FIRST PERSON

  • Open Access
    First person – Tiyasha Sarkar
    Biology Open 2020 9: bio056267 doi: 10.1242/bio.056267 Published 24 September 2020
  • Open Access
    First person – Komal Panchal
    Biology Open 2020 9: bio055632 doi: 10.1242/bio.055632 Published 3 September 2020
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Biology Open: 9 (9)
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
    PDF
  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
    PDF
  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
    PDF
  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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