Cover image

Cover: Glioblastoma single brain hemisphere section from Drosophila third-instar larvae, from a study by Portela and colleagues. Glia are labelled with Ihog-RFP (blue/red/magenta montage image) driven by repo-Gal4 to visualise tumour microtubes in glial cells. Egr protein is visualised by GFP staining of Egr-GFP protein fusion reporter (green/cyan/yellow in the montage image). In glioblastoma brain sections, Egr-GFP signal relocates from the healthy surrounding cells towards the glioblastoma tumour microtubes to activate the JNK signalling pathway in the tumour that is necessary for tumour progression and for the infiltration of the tumour into the brain. Image licensed under a Creative Commons Attribution 4.0 International license.