RT Journal Article
SR Electronic
T1 Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
JF Biology Open
JO Biology Open
FD Company of Biologists
SP bio030726
DO 10.1242/bio.030726
VO 7
IS 1
A1 Grigura, Vadim
A1 Barbier, Megan
A1 Zarov, Anna P.
A1 Kaufman, Charles K.
YR 2018
UL http://bio.biologists.org/content/7/1/bio030726.abstract
AB The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.