Aβ42
- Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.