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Alternative splicing

  • RESEARCH ARTICLE
    Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent alternative promoter usage during mouse early embryogenesis
    Xukun Lu, Zhen-Ao Zhao, Xiaoqing Wang, Xiaoxin Zhang, Yanhua Zhai, Wenbo Deng, Zhaohong Yi, Lei Li
    Biology Open 2018 7: bio032508 doi: 10.1242/bio.032508 Published 28 March 2018

    Summary: This study seeks to capture the alternative splicing landscape during mouse gastrulation, underlining the potential importance of alternative promoter usage in mammalian early embryogenesis.

  • RESEARCH ARTICLE
    The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration
    Stephanie Spannl, Alexandra Kumichel, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
    Biology Open 2017 6: 165-175; doi: 10.1242/bio.020040

    Summary: Loss of Crb_C, one protein isoform encoded by Drosophila crumbs, results in light-dependent retinal degeneration, but does not affect any of the other crumbs-specific functions.

  • RESEARCH ARTICLE
    Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization
    Sujeet Kumar, Sreejit Parameswaran, Rajendra K. Sharma
    Biology Open 2015 4: 1679-1687; doi: 10.1242/bio.012831

    Summary: Dual acylation (i.e. myristoylation and palmitoylation) regulates the atypical localization of sperm-specific hexokinase 1 isoform and thus is essential for ‘rewiring’ of glycolytic network.

  • RESEARCH ARTICLE
    Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development
    Roel Quintens, Tine Verreet, Ann Janssen, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Mieke Verslegers, Nada Samari, Giuseppe Pani, Joris Verheyde, Sarah Baatout, Mohammed A. Benotmane
    Biology Open 2015 4: 331-344; doi: 10.1242/bio.20149969

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