Angiogenesis
- Krüppel-like factor 6 mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and is aggravated by bone morphogenetic protein 9
Summary: Krüppel-like factor 6, which is triggered by pulmonary injury and promoted by bone morphogenetic protein 9, mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and then aggravates lung dysfunction.
- Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
Summary: Our study shows that the growth factor VEGF-A stimulates synthesis in endothelial cells of a proto-oncoprotein and protein kinase, Tpl2, and this is required for signal transduction and angiogenesis.
- Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer
Summary: We provided large-scale proteomic profiling of vascular endothelial cells in colorectal cancer with quantitative information, a number of potential antiangiogenic targets and a novel vision in the angiogenesis bio-mechanism of CRC.
- Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish
Summary: Overproduction of PGE2 causes inflammation and cancer and its blockage results in serious physiological consequences. This study investigated the novel roles of PGE2 in early vascular development of zebrafish.
- Characterization and in ovo vascularization of a 3D-printed hydroxyapatite scaffold with different extracellular matrix coatings under perfusion culture
Summary: Depending on the culture media, ECM coating of 3D-printed hydroxyapatite evokes different functional vascularization as assessed by CAM assay in ovo. ECM coating enhances vascularization compared to ECM-free hydroxyapatite.
- Physiological electric field works via the VEGF receptor to stimulate neovessel formation of vascular endothelial cells in a 3D environment
Summary: This study reports the effects of a direct current electrical field on endothelial neovessel formation in 3D culture. Endogenous EFs may promote angiogenesis of endothelial cells by activating the VEGF receptor signaling pathway.
- A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse
Summary: We have developed a novel reporter line, free from complicating factors associated with previous alleles, for monitoring Dll4 expression, at a cellular resolution, in the developing and adult mouse.
- Adjustable delivery of pro-angiogenic FGF-2 by alginate:collagen microspheres
Summary: The development of alginate:collagen composite hydrogel microspheres of adjustable size and degradation speed is described as a new platform for delivery of pro-angiogenic FGF-2 or pro-angiogenic cells.
- Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells
Summary: CUL3 and a CUL3-binding protein ANKFY1 determined the surface expression of integrin β1, an essential adhesion molecule for angiogenesis, by regulating the endosomal recycling traffic of integrin β1.
- Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.