Angiogenesis
- A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression
Summary: We developed a new treatment-naive quiescent rat choroidal neovascularization model by VEGF overexpression, allowing the long-term investigation of new drugs.
- Krüppel-like factor 6 mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and is aggravated by bone morphogenetic protein 9
Summary: Krüppel-like factor 6, which is triggered by pulmonary injury and promoted by bone morphogenetic protein 9, mediates pulmonary angiogenesis in rat experimental hepatopulmonary syndrome and then aggravates lung dysfunction.
- Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
Summary: Our study shows that the growth factor VEGF-A stimulates synthesis in endothelial cells of a proto-oncoprotein and protein kinase, Tpl2, and this is required for signal transduction and angiogenesis.
- Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer
Summary: We provided large-scale proteomic profiling of vascular endothelial cells in colorectal cancer with quantitative information, a number of potential antiangiogenic targets and a novel vision in the angiogenesis bio-mechanism of CRC.
- Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish
Summary: Overproduction of PGE2 causes inflammation and cancer and its blockage results in serious physiological consequences. This study investigated the novel roles of PGE2 in early vascular development of zebrafish.
- Characterization and in ovo vascularization of a 3D-printed hydroxyapatite scaffold with different extracellular matrix coatings under perfusion culture
Summary: Depending on the culture media, ECM coating of 3D-printed hydroxyapatite evokes different functional vascularization as assessed by CAM assay in ovo. ECM coating enhances vascularization compared to ECM-free hydroxyapatite.
- Physiological electric field works via the VEGF receptor to stimulate neovessel formation of vascular endothelial cells in a 3D environment
Summary: This study reports the effects of a direct current electrical field on endothelial neovessel formation in 3D culture. Endogenous EFs may promote angiogenesis of endothelial cells by activating the VEGF receptor signaling pathway.
- A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse
Summary: We have developed a novel reporter line, free from complicating factors associated with previous alleles, for monitoring Dll4 expression, at a cellular resolution, in the developing and adult mouse.
- Adjustable delivery of pro-angiogenic FGF-2 by alginate:collagen microspheres
Summary: The development of alginate:collagen composite hydrogel microspheres of adjustable size and degradation speed is described as a new platform for delivery of pro-angiogenic FGF-2 or pro-angiogenic cells.