Angiogenesis
- Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells
Summary: CUL3 and a CUL3-binding protein ANKFY1 determined the surface expression of integrin β1, an essential adhesion molecule for angiogenesis, by regulating the endosomal recycling traffic of integrin β1.
- Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
Summary: Depletion of AJAP1 in endothelial cells can increase angiogenic-like sprouting and cell migration. In addition, AJAP1 associates with microtubules in these cells.