Angiogenesis
- Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
Summary: Depletion of AJAP1 in endothelial cells can increase angiogenic-like sprouting and cell migration. In addition, AJAP1 associates with microtubules in these cells.