Apoptosis
- Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila
Summary: A new Drosophila diabetes model, where ER stress accumulation and apoptosis is induced in IPCs, showed diabetes-like phenotypes including reduced dilp mRNA, increased glucose concentration in hemolymph and growth inhibition.
- The therapeutic effect of controlled reoxygenation on chronic hypoxia-associated brain injury
Summary: Controlled reoxygenation may provide an effective therapeutic strategy for hypoxia-induced tissue injury via regulation of the JAK2/STAT3 signaling pathway. It will help make better informed clinical treatment decisions for cyanotic infants.
- Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia
Summary: Long non-coding RNA SNHG1 can facilitate the progression of acute myeloid leukemia by targeting an anti-tumor miR-101, and the upregulation of SNHG1 can predict poor prognosis in acute myeloid leukemia.
- Mechanical stress-induced cell death in breast cancer cells
Summary: Dynamic mechanical compressive stress loading applied to two different breast cancer cell lines results in mechanical stress-induced cell damage (MSICD) composed of apoptosis and necrosis.
- Identification of axolotl BH3-only proteins and expression in axolotl organs and apoptotic limb regeneration tissue
Summary: In our study we identified ten putative axolotl orthologs of the Bcl-2 family. We demonstrate that Bcl-2 family members are conserved in the axolotl and are involved in tissue degradation processes during limb regeneration.
- Enhanced survival of BCG-stimulated dendritic cells: involvement of anti-apoptotic proteins and NF-κB
Summary: BCG enhanced the survival of dendritic cells (DCs) and prolonged their lifespan. BCG promoted DC survival by up-regulating Bcl-2 and Bcl-xL. Increased survival of BCG-stimulated DCs was dependent on NF-κB, but was independent of MyD88 signaling.
- Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals
Summary: Inhibition of apoptosis in mouse embryos reveals rudiments of the lateral line system, a sensory system common to fish and aquatic amphibia, but hypothesized to be completely lost in amniotes.
- The teneurin C-terminal domain possesses nuclease activity and is apoptogenic
Summary: Teneurins are transmembrane proteins found in the developing nervous system that are related to bacterial toxins. Teneurins also have cytotoxic properties that may help regulate apoptosis or pruning.
- Gelsolin regulates proliferation, apoptosis and invasion in natural killer/T-cell lymphoma cells
Summary: GSN can suppress cell proliferation and invasion and promote apoptosis of YTS cells, and the PI3K/AKT signaling pathway is likely to be involved in this process.
- Bax-inhibiting peptide attenuates bleomycin-induced lung injury in mice
Summary: The inhibiting peptide for Bax, a pro-apoptotic member of the Bcl-2 family of proteins, ameliorates bleomycin-induced lung injury in mice via apoptosis suppression in epithelial cells.