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Apoptosis

  • FUTURE LEADER REVIEW
    Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease
    Olayemi Joseph Olajide, Marcus E. Suvanto, Clifton Andrew Chapman
    Biology Open 2021 10: bio056796 doi: 10.1242/bio.056796 Published 25 January 2021

    Summary: This review evaluated the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.

  • RESEARCH ARTICLE
    MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β
    Chi-Yung Chai, I.-Chun Tai, Rui Zhou, Junlong Song, Chaoying Zhang, Shengrong Sun
    Biology Open 2020 9: bio051904 doi: 10.1242/bio.051904 Published 21 December 2020

    Summary: Our findings provided a new role of miR-9-5p/PPAR in the occurrence and development of HS fibroblasts, promising a new target for HS.

  • RESEARCH ARTICLE
    Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy
    Xuelian Su, Haijing Zhou, Guangjie Bao, Jizeng Wang, Lin Liu, Qian Zheng, Manli Guo, Jinting Zhang
    Biology Open 2020 9: bio048108 doi: 10.1242/bio.048108 Published 30 March 2020

    Summary: Cellular mechanical damage is connected with the apoptosis of BMSCs, and the alterations in mechanics and nanomorphology could be used as a sensitive index to detect alterations in cell viability during apoptosis.

  • RESEARCH ARTICLE
    Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila
    Hiroka Katsube, Yukiko Hinami, Tatsuki Yamazoe, Yoshihiro H. Inoue
    Biology Open 2019 8: bio046524 doi: 10.1242/bio.046524 Published 20 December 2019

    Summary: A new Drosophila diabetes model, where ER stress accumulation and apoptosis is induced in IPCs, showed diabetes-like phenotypes including reduced dilp mRNA, increased glucose concentration in hemolymph and growth inhibition.

  • RESEARCH ARTICLE
    The therapeutic effect of controlled reoxygenation on chronic hypoxia-associated brain injury
    Zhenzhen Tu, Xingqin Tan, Shangyingying Li, Jie Cui, Shengfen Tu, Li Jiang
    Biology Open 2019 8: bio039370 doi: 10.1242/bio.039370 Published 11 December 2019

    Summary: Controlled reoxygenation may provide an effective therapeutic strategy for hypoxia-induced tissue injury via regulation of the JAK2/STAT3 signaling pathway. It will help make better informed clinical treatment decisions for cyanotic infants.

  • RESEARCH ARTICLE
    Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia
    Ming Tian, Wanjun Gong, Jingming Guo
    Biology Open 2019 8: bio046417 doi: 10.1242/bio.046417 Published 18 October 2019

    Summary: Long non-coding RNA SNHG1 can facilitate the progression of acute myeloid leukemia by targeting an anti-tumor miR-101, and the upregulation of SNHG1 can predict poor prognosis in acute myeloid leukemia.

  • RESEARCH ARTICLE
    Mechanical stress-induced cell death in breast cancer cells
    Satomi Takao, Minoru Taya, Cerwyn Chiew
    Biology Open 2019 8: bio043133 doi: 10.1242/bio.043133 Published 16 August 2019

    Summary: Dynamic mechanical compressive stress loading applied to two different breast cancer cell lines results in mechanical stress-induced cell damage (MSICD) composed of apoptosis and necrosis.

  • RESEARCH ARTICLE
    Identification of axolotl BH3-only proteins and expression in axolotl organs and apoptotic limb regeneration tissue
    Vesna Bucan, Claas-Tido Peck, Inas Nasser, Christina Liebsch, Peter M. Vogt, Sarah Strauß
    Biology Open 2018 7: bio036293 doi: 10.1242/bio.036293 Published 28 August 2018

    Summary: In our study we identified ten putative axolotl orthologs of the Bcl-2 family. We demonstrate that Bcl-2 family members are conserved in the axolotl and are involved in tissue degradation processes during limb regeneration.

  • RESEARCH ARTICLE
    Enhanced survival of BCG-stimulated dendritic cells: involvement of anti-apoptotic proteins and NF-κB
    Pawan Kumar, Vini John, Ananya Gupta, Sangeeta Bhaskar
    Biology Open 2018 7: bio032045 doi: 10.1242/bio.032045 Published 20 June 2018

    Summary: BCG enhanced the survival of dendritic cells (DCs) and prolonged their lifespan. BCG promoted DC survival by up-regulating Bcl-2 and Bcl-xL. Increased survival of BCG-stimulated DCs was dependent on NF-κB, but was independent of MyD88 signaling.

  • RESEARCH ARTICLE
    Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals
    Stefan Washausen, Wolfgang Knabe
    Biology Open 2018 7: bio031815 doi: 10.1242/bio.031815 Published 19 June 2018

    Summary: Inhibition of apoptosis in mouse embryos reveals rudiments of the lateral line system, a sensory system common to fish and aquatic amphibia, but hypothesized to be completely lost in amniotes.

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