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Autophagy

  • METHODS & TECHNIQUES
    Assessing methods to quantitatively validate TGFβ-dependent autophagy
    Charles B. Trelford, Gianni M. Di Guglielmo
    Biology Open 2020 9: bio055103 doi: 10.1242/bio.055103 Published 23 November 2020

    Summary: Using various tools including western blotting and immunofluorescence microscopy, it was observed that autophagic flux probes are the most robust tools to quantitatively assess cellular autophagy.

  • RESEARCH ARTICLE
    Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy
    Jingjing Wu, Youqile Wu, Xuemei Lian
    Biology Open 2020 9: bio053298 doi: 10.1242/bio.053298 Published 12 November 2020

    Summary: GRP78 is highly expressed in the lung cancer tissue, and targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by endoplasmic reticulum stress and autophagy.

  • RESEARCH ARTICLE
    Analysis of a cellular structure observed in the compound eyes of Drosophila white; yata mutants and white mutants
    Eri Arimoto, Yutaro Kawashima, Taein Choi, Mami Unagami, Shintaro Akiyama, Mizuki Tomizawa, Hiroyuki Yano, Emiko Suzuki, Masaki Sone
    Biology Open 2020 9: bio047043 doi: 10.1242/bio.047043 Published 13 January 2020

    Summary: We analysed a cellular structure formed by changes associated with exposure to light in the compound eyes of Drosophila white mutants, white; yata mutants and aged flies.

  • RESEARCH ARTICLE
    Autophagy-related Djatg8 is required for remodeling in planarian Dugesia japonica
    Jing Kang, Zimei Dong, Jing Wang, Guangwen Chen, Dezeng Liu
    Biology Open 2019 8: bio045013 doi: 10.1242/bio.045013 Published 3 December 2019

    Summary: The autophagy-related Djatg8 homologues Djatg8-2 and Djatg8-3 are required for planarian remodeling; we provide an emergent in vivo model organism to study autophagy and the molecular mechanism for planarian remodeling.

  • RESEARCH ARTICLE
    Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway
    Honggang Wang, Peiyu Zhong, Leilei Sun
    Biology Open 2019 8: bio043653 doi: 10.1242/bio.043653 Published 18 July 2019

    Summary: We prove that exogenous H2S can suppress NLRP3-mediated inflammation by promoting autophagy via the AMPK/mTOR pathway in L02 cells, providing insights into the anti-inflammatory mechanism of H2S.

  • RESEARCH ARTICLE
    Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy
    Zhanying Hu, Bo Chen, Qiong Zhao
    Biology Open 2019 8: bio040840 doi: 10.1242/bio.040840 Published 1 May 2019

    Summary: Our report of an essential regulation role of hedgehog signaling and autophagy on osteoblast differentiation may contribute to research on bone development biology, hedgehog signaling and the autophagy pathway.

  • RESEARCH ARTICLE
    The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells
    Carolina D'Alesio, Grazia Bellese, Maria Cristina Gagliani, Anastasia Lechiara, Martina Dameri, Elena Grasselli, Luisa Lanfrancone, Katia Cortese, Patrizio Castagnola
    Biology Open 2019 8: bio038323 doi: 10.1242/bio.038323 Published 18 April 2019

    Summary: Inhibition of CHD4 expression impairs cell proliferation and survival through downregulation of ERBB2 signaling and block of autophagy. Therefore, CHD4 should be considered a potential target in ERBB2+ breast cancers.

  • RESEARCH ARTICLE
    Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3
    Nicola J. Humphry, Sally P. Wheatley
    Biology Open 2018 7: bio037374 doi: 10.1242/bio.037374 Published 22 October 2018

    Summary: Survivin binds to LC3 through a canonical LIR, yet this interaction is not required for survivin overexpression to reduce autophagic flux, suggesting that survivin regulates autophagy via an alternative mechanism.

  • RESEARCH ARTICLE
    Inhibition of miR-34a-5p alleviates hypoxia-reoxygenation injury by enhancing autophagy in steatotic hepatocytes
    Chuanjiang Li, Kai Wang, Linghong Guo, Hang Sun, Hai Huang, XinXin Lin, Qingping Li
    Biology Open 2018 7: bio033290 doi: 10.1242/bio.033290 Published 26 March 2018

    Summary: Our study establishes an in vitro model for studying H/R injury in fatty liver, and shows that MiR-34a plays an important role in worsening H/R injury, likely by suppressing autophagy in steatotic hepatocytes.

  • RESEARCH ARTICLE
    Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes
    Peggy R. Biga, Mary N. Latimer, Jacob Michael Froehlich, Jean-Charles Gabillard, Iban Seiliez
    Biology Open 2017 6: 1720-1725; doi: 10.1242/bio.029090

    Summary: The role of nuclear events in the control of autophagy is underappreciated. This study demonstrates cell starvation associated gene expression changes and autophagy-specific histone modifications.

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