Bioelectricity
- Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential
Summary: We describe a simplified roadmap to study the role of bioelectricity, in particular individual ions, in cell biological processes.
- HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner
Summary: We identify a novel, developmental role for HCN4 channels and reveal a new Nodal-Lefty-Pitx2-independent, non-canonical mechanism upstream of organ positioning during embryonic left-right patterning. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.