Caenorhabditis elegans
- Nematicidal actions of the marigold exudate α-terthienyl: oxidative stress-inducing compound penetrates nematode hypodermis
Summary: α-terthienyl, an exudate of the marigold, effectively penetrates the nematode hypodermis in Caenorhabditis elegans dauer and Meloidogyne incognita J2 larvae, and exerts nematicidal activity through oxidative stress induction.
- PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
Summary: GFP tagging of endogenous GLP-1/Notch revealed life stage-specific differences in the nuclear accumulation of GLP-1 intracellular domain, which are mediated by the ubiquitin-proteolytic system and the splicing factor/E3 ubiquitin ligase PRP-19.
- The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan
Summary: This work uses a modular approach to combine five genes together to build worms that are long lived and much healthier than control animals, without a significant reduction in fertility. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion in Caenorhabditis elegans embryos
Summary: WASP-Arp2/3 regulates fusogen localization to intracellular vesicles in C. elegans embryos. Our results indicate that cell-cell fusions rely on distinct mechanisms at different developmental stages.
- Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos
Summary: The conserved protein kinase CK2 negatively regulates centrosome assembly and is required for proper cell cycle progression and cytokinesis in early C. elegans embryos.