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Caenorhabditis elegans

  • RESEARCH ARTICLE
    Nematicidal actions of the marigold exudate α-terthienyl: oxidative stress-inducing compound penetrates nematode hypodermis
    Takahiro Hamaguchi, Kazuki Sato, Cláudia S. L. Vicente, Koichi Hasegawa
    Biology Open 2019 8: bio038646 doi: 10.1242/bio.038646 Published 16 April 2019

    Summary: α-terthienyl, an exudate of the marigold, effectively penetrates the nematode hypodermis in Caenorhabditis elegans dauer and Meloidogyne incognita J2 larvae, and exerts nematicidal activity through oxidative stress induction.

  • RESEARCH ARTICLE
    PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
    Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
    Biology Open 2018 7: bio034066 doi: 10.1242/bio.034066 Published 16 July 2018

    Summary: GFP tagging of endogenous GLP-1/Notch revealed life stage-specific differences in the nuclear accumulation of GLP-1 intracellular domain, which are mediated by the ubiquitin-proteolytic system and the splicing factor/E3 ubiquitin ligase PRP-19.

  • RESEARCH ARTICLE
    The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan
    Dror Sagi
    Biology Open 2017 6: 1796-1801; doi: 10.1242/bio.027433

    Summary: This work uses a modular approach to combine five genes together to build worms that are long lived and much healthier than control animals, without a significant reduction in fertility. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion in Caenorhabditis elegans embryos
    Yan Zhang, Yihong Yang, Zhiwen Zhu, Guangshuo Ou
    Biology Open 2017 6: 1324-1328; doi: 10.1242/bio.026807

    Summary: WASP-Arp2/3 regulates fusogen localization to intracellular vesicles in C. elegans embryos. Our results indicate that cell-cell fusions rely on distinct mechanisms at different developmental stages.

  • RESEARCH ARTICLE
    Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos
    Jeffrey C. Medley, Megan M. Kabara, Michael D. Stubenvoll, Lauren E. DeMeyer, Mi Hye Song
    Biology Open 2017 6: 17-28; doi: 10.1242/bio.022418

    Summary: The conserved protein kinase CK2 negatively regulates centrosome assembly and is required for proper cell cycle progression and cytokinesis in early C. elegans embryos.

  • RESEARCH ARTICLE
    Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity
    Gauri Kulkarni, Zhennan Xu, Ahmed M. Mohamed, Haichang Li, Xia Tang, Gerard Limerick, William G. Wadsworth
    Biology Open 2013 2: 1300-1312; doi: 10.1242/bio.20136346

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