Calcium
- Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.
- Inhalation of marijuana affects Drosophila heart function
Summary: Marijuana induces early arrhythmogenesis and increases contractility in Drosophila. Our approach using this animal model allows us to carry out screenings to explore the impact of cannabinoids.
- Potassium fertilization arrests malate accumulation and alters soluble sugar metabolism in apple fruit
Summary: Optimized potassium levels not only reduce malate levels but also improve fructose and sucrose accumulation in apple fruit.
- Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
Summary: The excessive collagen secretory phenotype found in failing human hearts is associated with ventricular fibroblast remodeling, caused by an elevated influx of intracellular calcium via SOC channels.
- Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy
Summary: Dynamin 2 mutations cause centronuclear myopathy via unclear mechanisms. We show in a mouse model that changes in cytosolic calcium via incorrect membrane permeability correlate with muscle weakness.
- Expression and preliminary characterization of human MICU2
Summary: Ca2+ induces a monomer-dimer switch of MICU2, with the associated conformational change governed by its first EF-hand, but not influenced by the C-helix domain. A disulfide bond and salt bridge each contribute to MICU1-MICU2 heterodimer formation.