Cell migration
- MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
Summary: This work illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy.
- The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner
Summary: The Drosophila Cortactin-binding protein Nausicaa regulates actin branching and lamellipodial dynamics through its anchoring of Cortactin in the lamellipodia.
- Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
Summary: Our data indicate that GFRα1 functions cell-autonomously in subpopulations of OB interneuron precursors to regulate their generation and allocation in the mammalian OB.
- SERCA directs cell migration and branching across species and germ layers
Summary: Dynamic imaging of living embryos demonstrates that SERCA is a conserved regulator that controls cell migration and branching across species and germ layers, and PKC activation can rescue SERCA inhibition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
Summary: Depletion of AJAP1 in endothelial cells can increase angiogenic-like sprouting and cell migration. In addition, AJAP1 associates with microtubules in these cells.
- Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes
Summary: Using spatial and temporally controlled perturbations followed by live cell tracking in vivo, this paper demonstrates that directional movements downstream of Gbx2 and Otx2 are important for otic and lens placode formation.
- The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma
Summary: This paper demonstrates a functional link between a cancer-associated alteration to the tRNA repertoire and the invasive behaviour of cancer cells by demonstrating that increased tRNAimet can drive invasion and metastasis in melanoma cells.
- Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination
Summary: Twist1+ epithelium retains intercellular junctions and proliferative capacity. During dissemination, Twist1+ cells retain adhesive capacity and exhibit features of both amoeboid and mesenchymal migration modes.
- Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration
Summary: Tensin 1 links phosphorylated Cas to actin inward flux, facilitating the force transmission from the motile system (i.e. actomyosin contraction) to the stationary parts (i.e. adhesion complexes) in migrating cells.
- BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation
Summary: BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation, probably by protecting CXCR4 from degradation.