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Cell migration

  • RESEARCH ARTICLE
    RhoGAP RGA-8 supports morphogenesis in C. elegans by polarizing epithelia
    Hamidah Raduwan, Shashikala Sasidharan, Luigy Cordova Burgos, Andre G. Wallace, Martha C. Soto
    Biology Open 2020 9: bio056911 doi: 10.1242/bio.056911 Published 26 November 2020

    Summary: RGA-8, a protein with membrane binding and actin regulatory motifs, promotes embryonic morphogenesis by localizing active CDC-42 in developing epithelia, and controlling actin and actin motors during cell movements.

  • RESEARCH ARTICLE
    MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
    Peihong Su, Chong Yin, Dijie Li, Chaofei Yang, Xue Wang, Jiawei Pei, Ye Tian, Airong Qian
    Biology Open 2020 9: bio048173 doi: 10.1242/bio.048173 Published 24 March 2020

    Summary: This work illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy.

  • RESEARCH ARTICLE
    The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner
    Meghan E. O'Connell, Divya Sridharan, Tristan Driscoll, Ipsita Krishnamurthy, Wick G. Perry, Derek A. Applewhite
    Biology Open 2019 8: bio038232 doi: 10.1242/bio.038232 Published 17 June 2019

    Summary: The Drosophila Cortactin-binding protein Nausicaa regulates actin branching and lamellipodial dynamics through its anchoring of Cortactin in the lamellipodia.

  • RESEARCH ARTICLE
    Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
    Sabrina Zechel, Diana Fernandez-Suarez, Carlos F. Ibáñez
    Biology Open 2018 7: bio033753 doi: 10.1242/bio.033753 Published 18 May 2018

    Summary: Our data indicate that GFRα1 functions cell-autonomously in subpopulations of OB interneuron precursors to regulate their generation and allocation in the mammalian OB.

  • RESEARCH ARTICLE
    SERCA directs cell migration and branching across species and germ layers
    Danielle V. Bower, Nick Lansdale, Sonia Navarro, Thai V. Truong, Dan J. Bower, Neil C. Featherstone, Marilyn G. Connell, Denise Al Alam, Mark R. Frey, Le A. Trinh, G. Esteban Fernandez, David Warburton, Scott E. Fraser, Daimark Bennett, Edwin C. Jesudason
    Biology Open 2017 6: 1458-1471; doi: 10.1242/bio.026039

    Summary: Dynamic imaging of living embryos demonstrates that SERCA is a conserved regulator that controls cell migration and branching across species and germ layers, and PKC activation can rescue SERCA inhibition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
    Katharina Hötte, Isabell Smyrek, Anna Starzinski-Powitz, Ernst H. K. Stelzer
    Biology Open 2017 6: 723-731; doi: 10.1242/bio.022335

    Summary: Depletion of AJAP1 in endothelial cells can increase angiogenic-like sprouting and cell migration. In addition, AJAP1 associates with microtubules in these cells.

  • RESEARCH ARTICLE
    Directional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes
    Ben Steventon, Roberto Mayor, Andrea Streit
    Biology Open 2016 5: 1620-1624; doi: 10.1242/bio.020966

    Summary: Using spatial and temporally controlled perturbations followed by live cell tracking in vivo, this paper demonstrates that directional movements downstream of Gbx2 and Otx2 are important for otic and lens placode formation.

  • RESEARCH ARTICLE
    The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma
    Joanna Birch, Cassie J. Clarke, Andrew D. Campbell, Kirsteen Campbell, Louise Mitchell, Dritan Liko, Gabriela Kalna, Douglas Strathdee, Owen J. Sansom, Matthew Neilson, Karen Blyth, Jim C. Norman
    Biology Open 2016 5: 1371-1379; doi: 10.1242/bio.019075

    Summary: This paper demonstrates a functional link between a cancer-associated alteration to the tRNA repertoire and the invasive behaviour of cancer cells by demonstrating that increased tRNAimet can drive invasion and metastasis in melanoma cells.

  • RESEARCH ARTICLE
    Twist1-positive epithelial cells retain adhesive and proliferative capacity throughout dissemination
    Eliah R. Shamir, Kester Coutinho, Dan Georgess, Manfred Auer, Andrew J. Ewald
    Biology Open 2016 5: 1216-1228; doi: 10.1242/bio.019703

    Summary: Twist1+ epithelium retains intercellular junctions and proliferative capacity. During dissemination, Twist1+ cells retain adhesive capacity and exhibit features of both amoeboid and mesenchymal migration modes.

  • RESEARCH ARTICLE
    Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration
    Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada
    Biology Open 2016 5: 499-506; doi: 10.1242/bio.016428

    Summary: Tensin 1 links phosphorylated Cas to actin inward flux, facilitating the force transmission from the motile system (i.e. actomyosin contraction) to the stationary parts (i.e. adhesion complexes) in migrating cells.

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