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CFTR

  • RESEARCH ARTICLE
    Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells
    Barbara Dhooghe, Caroline Bouzin, Angélique Mottais, Emmanuel Hermans, Martial Delion, Nadtha Panin, Sabrina Noel, Teresinha Leal
    Biology Open 2020 9: bio053116 doi: 10.1242/bio.053116 Published 25 August 2020

    Summary: Our findings support the view that vardenafil, a phosphodiesterase type 5 inhibitor, partially rescues F508del protein through cGMP/PKG-independent mechanisms in cystic fibrosis cell line.

  • RESEARCH ARTICLE
    WNK1 and p38-MAPK distribution in ionocytes and accessory cells of euryhaline teleost fish implies ionoregulatory function
    W. S. Marshall, R. R. F. Cozzi, M. Spieker
    Biology Open 2017 6: 956-966; doi: 10.1242/bio.024232

    Summary: Fish opercular epithelium ionocytes and accessory cells have WNK family kinases that may regulate paracellular and transcellular ion transport.

  • RESEARCH ARTICLE
    Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice
    Barbara Dhooghe, Charlotte Bouckaert, Arnaud Capron, Pierre Wallemacq, Teresinha Leal, Sabrina Noel
    Biology Open 2015 4: 929-936; doi: 10.1242/bio.010967

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