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Chaperone

  • RESEARCH ARTICLE
    Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
    Eleni I. Theotoki, Athanassios D. Velentzas, Stamatia A. Katarachia, Nikos C. Papandreou, Nikolas I. Kalavros, Sofia N. Pasadaki, Aikaterini F. Giannopoulou, Panagiotis Giannios, Vassiliki A. Iconomidou, Eumorphia G. Konstantakou, Ema Anastasiadou, Issidora S. Papassideri, Dimitrios J. Stravopodis
    Biology Open 2019 8: bio046961 doi: 10.1242/bio.046961 Published 15 October 2019

    Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.

  • RESEARCH ARTICLE
    Analysis of novel hyperosmotic shock response suggests ‘beads in liquid’ cytosol structure
    Alexander I. Alexandrov, Erika V. Grosfeld, Alexander A. Dergalev, Vitaly V. Kushnirov, Roman N. Chuprov-Netochin, Pyotr A. Tyurin-Kuzmin, Igor I. Kireev, Michael D. Ter-Avanesyan, Sergey V. Leonov, Michael O. Agaphonov
    Biology Open 2019 8: bio044529 doi: 10.1242/bio.044529 Published 10 July 2019

    Summary: We describe a novel cellular response to hyperosmotic shock – rapid reversible formation of foci by various proteins. Data on foci behavior suggest a novel ‘beads in liquid’ cytosolic structure.

  • RESEARCH ARTICLE
    Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress
    Sebastian Ibstedt, Theodora C. Sideri, Chris M. Grant, Markus J. Tamás
    Biology Open 2014 3: 913-923; doi: 10.1242/bio.20148938
  • RESEARCH ARTICLE
    Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins
    Jorge Cuellar, Hugo Yébenes, Sandra K. Parker, Gerardo Carranza, Marina Serna, José María Valpuesta, Juan Carlos Zabala, H. William Detrich III
    Biology Open 2014 3: 261-270; doi: 10.1242/bio.20147427

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