Cholesterol
- Treatment with methyl-β-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model
Summary: The role and mechanism of cholesterol-rich membrane integrity in pain development for small-fiber neuropathy remains unclear. Depletion of membrane cholesterol contents preserves functional PAP profiles and the antinociceptive effect after RTX neuropathy.
- A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model
Summary: An LDL receptor knockout rat model was generated which offers a new hypercholesterolemia model. A lipidomics analysis reveals hepatic lipid signatures associating with LDLR deficiency in rats.