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Cholesterol

  • RESEARCH ARTICLE
    Treatment with methyl-β-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model
    Chih-Lung Lin, Chin-Hong Chang, Ying-Shuang Chang, Shui-Chin Lu, Yu-Lin Hsieh
    Biology Open 2019 8: bio039511 doi: 10.1242/bio.039511 Published 14 January 2019

    Summary: The role and mechanism of cholesterol-rich membrane integrity in pain development for small-fiber neuropathy remains unclear. Depletion of membrane cholesterol contents preserves functional PAP profiles and the antinociceptive effect after RTX neuropathy.

  • RESEARCH ARTICLE
    A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model
    Hong Yu Wang, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, Liang Chen, Wei Yang, Liu Yang, Qiaoli Chen, Bin Shen, Bian Hu, Zhihong Zheng, Haibo Zhu, Xingxu Huang, Guowang Xu, Shuai Chen
    Biology Open 2016 5: 979-986; doi: 10.1242/bio.019802

    Summary: An LDL receptor knockout rat model was generated which offers a new hypercholesterolemia model. A lipidomics analysis reveals hepatic lipid signatures associating with LDLR deficiency in rats.

  • RESEARCH ARTICLE
    Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila
    Antoine Ducuing, Bertrand Mollereau, Jeffrey D. Axelrod, Stephane Vincent
    Biology Open 2013 2: 596-604; doi: 10.1242/bio.20134952

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