Collagen
- The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program
Summary: We define the spectrum of phenotypic abnormalities linked with Col4a2 disruption and demonstrate the opportunities the Deciphering the Mechanisms of Developmental Disorders (DMDD) program offers for exploring rare human diseases.
- Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate
Summary: This study provides a rare connection between beta catenin and ectodysplasin A receptor in an endoderm derived tissue and presents a potential mechanism for collagen accumulation in the prostate.
- An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix
Summary: Using an immunofluorescence extracellular matrix, we show that epithelial cells can deposit extracellular matrix components in a comparable manner to fibroblasts highlighting their role as potential targets in fibrotic disease.
- Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae
Summary: This study reveals the architecture, molecular composition and dynamic expression profile of the extracellular matrix in ascidian embryos and larvae, providing clues for its function in chordate development.