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Collagen

  • RESEARCH ARTICLE
    Unique histological features of the tail skin of cotton rat (Sigmodon hispidus) related to caudal autotomy
    Marina Hosotani, Teppei Nakamura, Osamu Ichii, Takao Irie, Yuji Sunden, Yaser Hosny Ali Elewa, Takafumi Watanabe, Hiromi Ueda, Takashi Mishima, Yasuhiro Kon
    Biology Open 2021 10: bio058230 doi: 10.1242/bio.058230 Published 19 February 2021

    Summary: The unique histological structures in derimis, subcutis and coccygeal artery of the tail skin are related to the caudal autotomy mechanism in the cotton rat.

  • RESEARCH ARTICLE
    The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program
    Lukas F. Reissig, Anna Nele Herdina, Julia Rose, Barbara Maurer-Gesek, Jenna L. Lane, Fabrice Prin, Robert Wilson, Emily Hardman, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Icoresi-Mazzeo, Jacqueline K. White, Ed Ryder, Diane Gleeson, David J. Adams, Stefan H. Geyer, Timothy J. Mohun, Wolfgang J. Weninger
    Biology Open 2019 8: bio042895 doi: 10.1242/bio.042895 Published 1 August 2019

    Summary: We define the spectrum of phenotypic abnormalities linked with Col4a2 disruption and demonstrate the opportunities the Deciphering the Mechanisms of Developmental Disorders (DMDD) program offers for exploring rare human diseases.

  • RESEARCH ARTICLE
    Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate
    Kyle A. Wegner, Vatsal Mehta, Jeanette A. Johansson, Brett R. Mueller, Kimberly P. Keil, Lisa L. Abler, Paul C. Marker, M. Mark Taketo, Denis J. Headon, Chad M. Vezina
    Biology Open 2019 8: bio037945 doi: 10.1242/bio.037945 Published 18 March 2019

    Summary: This study provides a rare connection between beta catenin and ectodysplasin A receptor in an endoderm derived tissue and presents a potential mechanism for collagen accumulation in the prostate.

  • RESEARCH ARTICLE
    An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix
    Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson
    Biology Open 2017 6: 1423-1433; doi: 10.1242/bio.025866

    Summary: Using an immunofluorescence extracellular matrix, we show that epithelial cells can deposit extracellular matrix components in a comparable manner to fibroblasts highlighting their role as potential targets in fibrotic disease.

  • RESEARCH ARTICLE
    Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae
    Jiankai Wei, Guilin Wang, Xiang Li, Ping Ren, Haiyan Yu, Bo Dong
    Biology Open 2017 6: 1383-1390; doi: 10.1242/bio.026336

    Summary: This study reveals the architecture, molecular composition and dynamic expression profile of the extracellular matrix in ascidian embryos and larvae, providing clues for its function in chordate development.

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