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Copper

  • RESEARCH ARTICLE
    Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
    Eleni I. Theotoki, Athanassios D. Velentzas, Stamatia A. Katarachia, Nikos C. Papandreou, Nikolas I. Kalavros, Sofia N. Pasadaki, Aikaterini F. Giannopoulou, Panagiotis Giannios, Vassiliki A. Iconomidou, Eumorphia G. Konstantakou, Ema Anastasiadou, Issidora S. Papassideri, Dimitrios J. Stravopodis
    Biology Open 2019 8: bio046961 doi: 10.1242/bio.046961 Published 15 October 2019

    Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.

  • RESEARCH ARTICLE
    The neurotoxic effects of hydrogen peroxide and copper in Retzius nerve cells of the leech Haemopis sanguisuga
    Zorica D. Jovanovic, Marija B. Stanojevic, Vladimir B. Nedeljkov
    Biology Open 2016 5: 381-388; doi: 10.1242/bio.014936

    Summary: This characterization of the early changes in physiological membrane properties of Retzius neurons provides evidence for the oxidative modification of outward potassium channels.

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