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Development

  • RESEARCH ARTICLE
    A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes
    Paul J. Vorster, Paul Goetsch, Tilini U. Wijeratne, Keelan Z. Guiley, Laura Andrejka, Sarvind Tripathi, Braden J. Larson, Seth M. Rubin, Susan Strome, Joseph S. Lipsick
    Biology Open 2020 9: bio051508 doi: 10.1242/bio.051508 Published 7 May 2020

    Summary: Despite nematodes having lost their animal-type Myb proteins 500 million years ago, the Caenorhabditis elegans MuvB complex still functionally interacts with the Drosophila melanogaster Myb protein in vitro and in vivo.

  • RESEARCH ARTICLE
    Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish
    Nayeli G. Reyes-Nava, Hung-Chun Yu, Curtis R. Coughlin II, Tamim H. Shaikh, Anita M. Quintana
    Biology Open 2020 9: bio051367 doi: 10.1242/bio.051367 Published 13 April 2020

    Summary: By coupling human medical genetics and in vivo functional analysis we show that GABRA1 regulates motility and the expression of specific subunits of the GABAA receptor during zebrafish development.

  • RESEARCH ARTICLE
    Loss of Crb2b-lf leads to anterior segment defects in old zebrafish
    Satu Kujawski, Cátia Crespo, Marta Luz, Michaela Yuan, Sylke Winkler, Elisabeth Knust
    Biology Open 2020 9: bio047555 doi: 10.1242/bio.047555 Published 11 February 2020

    Summary: Loss of the apico-basal polarity regulator Crb2b-lf does not affect retinal development but leads to ocular anterior segment defects in old zebrafish.

  • RESEARCH ARTICLE
    Larval mannitol diets increase mortality, prolong development and decrease adult body sizes in fruit flies (Drosophila melanogaster)
    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
    Biology Open 2019 8: bio047084 doi: 10.1242/bio.047084 Published 2 January 2020

    Summary: Mannitol, a sugar polyol, decreases body size and survival and prolongs development in larval Drosophila melanogaster. The timing of introduction during development affects the magnitude of mannitol's impact on larvae.

  • RESEARCH ARTICLE
    Characteristics and function of a novel cystatin gene in the pine wood nematode Bursaphelenchus xylophilus
    Qi Xue, Xiao-Qin Wu
    Biology Open 2019 8: bio042655 doi: 10.1242/bio.042655 Published 18 September 2019

    Summary: Bx-cpi-1, a variant of a type II cystatin gene, was abundantly expressed in the reproductive organs of Bursaphelenchus xylophilus, and involved in the development and pathogenicity of B. xylophilus.

  • RESEARCH ARTICLE
    Accuracy of fruit-fly eclosion rhythms evolves by strengthening circadian gating rather than developmental fine-tuning
    Vishwanath Varma, Shambhavi Krishna, Manishi Srivastava, Vijay Kumar Sharma, Vasu Sheeba
    Biology Open 2019 8: bio042176 doi: 10.1242/bio.042176 Published 27 August 2019

    Summary: Fruit fly populations that have evolved greater accuracy of eclosion rhythms show enhanced gating of their eclosion by circadian clocks but not reduced variation in clock-independent developmental processes.

  • RESEARCH ARTICLE
    Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus
    Rebecca S. McGreal-Estrada, Louise V. Wolf, Ales Cvekl
    Biology Open 2018 7: bio036897 doi: 10.1242/bio.036897 Published 7 December 2018

    Summary: The αA-crystallin ranks amongst the most highly expressed tissue-specific genes. It is an advantageous model system to probe both promoter-enhancer looping and to identify distal enhancers and their temporal/spatial activities.

  • RESEARCH ARTICLE
    Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52) is essential for preimplantation embryo development
    Jiude Mao, Chad O'Gorman, Miriam Sutovsky, Michal Zigo, Kevin D. Wells, Peter Sutovsky
    Biology Open 2018 7: bio035717 doi: 10.1242/bio.035717 Published 2 October 2018

    Summary: Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52), a ubiquitin-ribosomal fusion gene, is a major source of ubiquitin protein for covalent modification of proteinaceous substrates recycled by ubiquitin-proteasome system. Using CRISPR/cas9 gene editing tool, we demonstrate that that Uba52 gene is essential in early embryogenesis in mammals.

  • METHODS & TECHNIQUES
    High-throughput live-imaging of embryos in microwell arrays using a modular specimen mounting system
    Seth Donoughe, Chiyoung Kim, Cassandra G. Extavour
    Biology Open 2018 7: bio031260 doi: 10.1242/bio.031260 Published 9 July 2018

    Summary: This Methods & Techniques article describes a customizable device for mounting and live-imaging a wide range of tissues and species; complete design files and instructions for assembly are included.

  • RESEARCH ARTICLE
    The teneurin C-terminal domain possesses nuclease activity and is apoptogenic
    Jacqueline Ferralli, Richard P. Tucker, Ruth Chiquet-Ehrismann
    Biology Open 2018 7: bio031765 doi: 10.1242/bio.031765 Published 19 March 2018

    Summary: Teneurins are transmembrane proteins found in the developing nervous system that are related to bacterial toxins. Teneurins also have cytotoxic properties that may help regulate apoptosis or pruning.

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