Drosophila
- Smoking flies: testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster
Summary: Nicotine, a substance present in tobacco, resembles insecticide compounds such as neonicotinoids, and affects the heart function in Drosophila melanogaster.
- A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology
Summary: Using Drosophila as a model system, we identify F-actin and microtubules as important determinants of how cells and tissues respond to Shroom induced contractility.
- Wound-induced polyploidization is dependent on Integrin-Yki signaling
Summary: Conserved focal adhesion genes, mys and Fak, enable efficient wound repair by inducing polyploid cell growth via cell fusion and Yki-dependent endoreplication.
- Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue
Summary: Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue.
- Quantifying Drosophila adults with the use of a smartphone
Summary: We offer a highly accurate and efficient method for an automatic calculation of Drosophila melanogaster imagoes with the use of the SeedCounter application for mobile devices running Android operating system.
- Sleep-length differences are associated with altered longevity in the fruit fly Drosophila melanogaster
Summary: We show that fruit flies with shortened sleep patterns have decreased aging rates and increased longevity, while flies with disrupted circadian rhythm have decreased longevity. Our data suggests that circadian and sleep systems interact differentially with mechanisms of aging.
- Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density
Summary: The retrograde vesicle tethering factor, Vps54, regulates development of the Drosophila larval NMJ. Moreover, presynaptic Vps54 interacts genetically with the small GTPase, Rab7, to control NMJ growth and postsynaptic density composition.
- Compartment and cell-type specific hypoxia responses in the developing Drosophila brain
Summary: A fluorescent biosensor reveals cell type specific hypoxia levels in the Drosophila brain in unprecedented detail. It paves the way for further functional studies addressing the role of oxygen in neural stem cell maintenance and differentiation.
- A gum Arabic assisted sustainable drug delivery system for adult Drosophila
Summary: Drug insolubility and a lack of a continuous delivery system are big challenges for large-scale compound screenings in flies. The authors developed a U-GLAD system that can successfully solve these issues.