Drosophila
- A gum Arabic assisted sustainable drug delivery system for adult Drosophila
Summary: Drug insolubility and a lack of a continuous delivery system are big challenges for large-scale compound screenings in flies. The authors developed a U-GLAD system that can successfully solve these issues.
- Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies
Summary: Nucleolar stress (loss of ribosome production/function) in certain human progenitor or stem cells results in disease. In fruit flies, larval mushroom body neuroblasts are relatively resilient to nucleolar stress.
- Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
Summary: Ca2+ dysregulation in cardiomyocytes is a common feature of cardiomyopathy and heart failure pathogenesis. Here we demonstrate in Drosophila melanogaster that store-operated Ca2+ entry is essential for physiological heart function.
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
Summary: Enhancing mitochondria–ER contacts ameliorates locomotor phenotypes and extends lifespan in a fly model of Alzheimer's disease.
- Analysis of a cellular structure observed in the compound eyes of Drosophila white; yata mutants and white mutants
Summary: We analysed a cellular structure formed by changes associated with exposure to light in the compound eyes of Drosophila white mutants, white; yata mutants and aged flies.
- Visualisation of ribosomes in Drosophila axons using Ribo-BiFC
Summary: We described a novel straightforward technique termed Ribo-BiFC to visualise assembled ribosomes in Drosophila cells. This technique revealed ribosomes in axons of both developing and mature neurons.
- Endoplasmic reticulum stress-induced cellular dysfunction and cell death in insulin-producing cells results in diabetes-like phenotypes in Drosophila
Summary: A new Drosophila diabetes model, where ER stress accumulation and apoptosis is induced in IPCs, showed diabetes-like phenotypes including reduced dilp mRNA, increased glucose concentration in hemolymph and growth inhibition.
- Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation
Summary: Fruit fly germline stem cell differentiation is accompanied by major changes of the transcriptome that may be regulated at the post-transcriptional level.
- Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut
Summary: Heparan sulfate chains in Drosophila adult intestinal stem cells negatively regulate stem cell proliferation and differentiation to control tissue homeostasis under physiological conditions.
- Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.