Drosophila
- Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut
Summary: Heparan sulfate chains in Drosophila adult intestinal stem cells negatively regulate stem cell proliferation and differentiation to control tissue homeostasis under physiological conditions.
- Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.
- The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation
Summary: In the parasitic wasp Nasonia, Tsl, a key component of the process that defines the termini of the embryo of Drosophila, has a function in the structure of the vitelline membrane.
- The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Summary: The analysis of Chmp5 and Ist1, which belong to the two ESCRT auxiliary sub-complexes in Drosophila, suggests that these ESCRT proteins provide robustness against cold in diverse poikilothermic organisms.
- Accuracy of fruit-fly eclosion rhythms evolves by strengthening circadian gating rather than developmental fine-tuning
Summary: Fruit fly populations that have evolved greater accuracy of eclosion rhythms show enhanced gating of their eclosion by circadian clocks but not reduced variation in clock-independent developmental processes.
- Inhalation of marijuana affects Drosophila heart function
Summary: Marijuana induces early arrhythmogenesis and increases contractility in Drosophila. Our approach using this animal model allows us to carry out screenings to explore the impact of cannabinoids.
- Lineage-specific determination of ring neuron circuitry in the central complex of Drosophila
Summary: The formation of ring neurons is described from a pair of embryonic stem cells to engrailed and Poxn neuro-dependent lineage-specific determination of neural circuits in the central complex of Drosophila.
- Intestinal lipid droplets as novel mediators of host–pathogen interaction in Drosophila
Summary: Lipid droplets are inducible organelles, act as inflammatory markers and, depending on the nature of challenge, can dictate the outcome of the infection.
- The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4
Summary: In this study, we find that crizotinib extends the lifespan of Drosophila overexpressing hTPM4-ALK and hTPM4, which are linked with a variety of human tumors.
- Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developing Drosophila eye
Summary: N-Cadherin adherens junction formation in the Drosophila larval eye imaginal disc is controlled by the combined functions of the p21-activated kinase Mbt/PAK4 and the kinases Src64 and Src42.