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Drosophila melanogaster

  • RESEARCH ARTICLE
    A glucose-supplemented diet enhances gut barrier integrity in Drosophila
    Anthony Galenza, Edan Foley
    Biology Open 2021 10: bio056515 doi: 10.1242/bio.056515 Published 8 March 2021

    Summary: How diet affects lifespan has received much attention. We found that maintenance of intestinal barrier integrity is likely an important factor in glucose-dependent lifespan extension in flies.

  • RESEARCH ARTICLE
    Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity
    Yang Cheng, Jiadong Cai, Yuanyuan Fu, Congjing Feng, Yue Hao, Youheng Wei
    Biology Open 2020 9: bio054999 doi: 10.1242/bio.054999 Published 6 November 2020

    Summary: Royal jelly (RJ) modulates the reactive oxygen species (ROS) levels and some metabolic defects that associated with hyper TORC1 activity in a Drosophila model.

  • RESEARCH ARTICLE
    Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology in Drosophila melanogaster
    Constance G. Weismann, Anna Blice-Baum, Tangji Tong, Joyce Li, Brendan K. Huang, Stephan M. Jonas, Anthony Cammarato, Michael A. Choma
    Biology Open 2019 8: bio044339 doi: 10.1242/bio.044339 Published 27 August 2019

    Summary: Mutant troponin I increases aortic and myocardial stiffness and engenders histologic abnormalities in fruit flies.

  • RESEARCH ARTICLE
    Evidence of dietary protein restriction regulating pupation height, development time and lifespan in Drosophila melanogaster
    Sudhakar Krittika, Alisha Lenka, Pankaj Yadav
    Biology Open 2019 8: bio042952 doi: 10.1242/bio.042952 Published 6 June 2019

    Summary: In studying protein-restricted diet-mediated interplay between major traits during pre-adult to adult stages in Drosophila melanogaster, we found various existing positive and negative correlations being challenged and supported upon differing diets.

  • RESEARCH ARTICLE
    Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster
    Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi
    Biology Open 2019 8: bio043372 doi: 10.1242/bio.043372 Published 30 May 2019

    Summary: Our Drosophila studies indicate the lack of a marked, coordinated response towards unanchored poly-ubiquitin in flies, suggesting that untethered ubiquitin chains are not necessarily problematic in intact organisms.

  • RESEARCH ARTICLE
    Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe of Drosophila melanogaster
    Lynn M. Riddiford, James W. Truman, Aljoscha Nern
    Biology Open 2018 7: bio034025 doi: 10.1242/bio.034025 Published 23 April 2018

    Summary: Developmental gradients and steroid surges interact during optic lobe development. Early, ectopic juvenile hormone treatment alters steroid receptor levels, suppresses late events but not early events linked to developmental gradients.

  • RESEARCH ARTICLE
    AβPP processing results in greater toxicity per amount of Aβ1-42 than individually expressed and secreted Aβ1-42 in Drosophila melanogaster
    Liza Bergkvist, Linnea Sandin, Katarina Kågedal, Ann-Christin Brorsson
    Biology Open 2016 5: 1030-1039; doi: 10.1242/bio.017194

    Summary: In Drosophila, the proteotoxic effect of Aβ1-42 is highly dependent on how and where the peptide is generated, rather than on the peptide level in the flies, with implications for Alzheimer's disease research.

  • METHODS & TECHNIQUES
    Functional characterisation of human synaptic genes expressed in the Drosophila brain
    Lysimachos Zografos, Joanne Tang, Franziska Hesse, Erich E. Wanker, Ka Wan Li, August B. Smit, R. Wayne Davies, J. Douglas Armstrong
    Biology Open 2016 5: 662-667; doi: 10.1242/bio.016261

    Summary: This report describes a resource collection of Drosophila melanogaster strains expressing human synaptic genes and methods that can be applied in order to investigate the genes' function.

  • RESEARCH ARTICLE
    The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage
    Pia C. Svendsen, Jae-Ryeon Ryu, William J. Brook
    Biology Open 2015 4: 1707-1714; doi: 10.1242/bio.013565

    Summary: Leg expression of the selector gene midline in Drosophila is controlled both by transcriptional regulation and by the lack of mixing between dorsal and ventral cells in the distal leg.

  • RESEARCH ARTICLE
    Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless
    Laura Tamberg, Mari Sepp, Tõnis Timmusk, Mari Palgi
    Biology Open 2015 4: 1762-1771; doi: 10.1242/bio.014696

    Summary: Introducing mutations of the TCF4 gene found in human patients into its fly orthologue daughterless allows the generation of Drosophila models for research into Pitt-Hopkins syndrome.

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