Drosophila melanogaster
- Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology in Drosophila melanogaster
Summary: Mutant troponin I increases aortic and myocardial stiffness and engenders histologic abnormalities in fruit flies.
- Evidence of dietary protein restriction regulating pupation height, development time and lifespan in Drosophila melanogaster
Summary: In studying protein-restricted diet-mediated interplay between major traits during pre-adult to adult stages in Drosophila melanogaster, we found various existing positive and negative correlations being challenged and supported upon differing diets.
- Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster
Summary: Our Drosophila studies indicate the lack of a marked, coordinated response towards unanchored poly-ubiquitin in flies, suggesting that untethered ubiquitin chains are not necessarily problematic in intact organisms.
- Juvenile hormone reveals mosaic developmental programs in the metamorphosing optic lobe of Drosophila melanogaster
Summary: Developmental gradients and steroid surges interact during optic lobe development. Early, ectopic juvenile hormone treatment alters steroid receptor levels, suppresses late events but not early events linked to developmental gradients.
- AβPP processing results in greater toxicity per amount of Aβ1-42 than individually expressed and secreted Aβ1-42 in Drosophila melanogaster
Summary: In Drosophila, the proteotoxic effect of Aβ1-42 is highly dependent on how and where the peptide is generated, rather than on the peptide level in the flies, with implications for Alzheimer's disease research.
- Functional characterisation of human synaptic genes expressed in the Drosophila brain
Summary: This report describes a resource collection of Drosophila melanogaster strains expressing human synaptic genes and methods that can be applied in order to investigate the genes' function.
- The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage
Summary: Leg expression of the selector gene midline in Drosophila is controlled both by transcriptional regulation and by the lack of mixing between dorsal and ventral cells in the distal leg.
- Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless
Summary: Introducing mutations of the TCF4 gene found in human patients into its fly orthologue daughterless allows the generation of Drosophila models for research into Pitt-Hopkins syndrome.