Drosophila
- The ATPase TER94 regulates Notch signaling during Drosophila wing development
Summary: Our study demonstrates that the ATPase TER94 and the p47 adaptor positively regulate Notch signaling during Drosophila wing development, thus establishing a functional interaction between TER94 and Notch signaling activity.
- Contribution of non-circadian neurons to the temporal organization of locomotor activity
Summary: Here we characterized the impact of different putative postsynaptic partners of the sLNvs on the control of rhythmic locomotor behavior. We found that some of these novel neuronal clusters are relevant for the control of locomotor activity.
- Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
Summary: Cells that gain or lose chromosomes during cell division are shown to be sensitive to ATP levels and protein folding stress.
- Drosophila mef2 is essential for normal mushroom body and wing development
Summary: Drosophila mef2 expression is restricted to subsets of mushroom body neurons, from the time of their differentiation to adulthood, and is essential for mushroom body formation.
- The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila
Summary: Drosophila Arl8 is essential for viability and is required for normal functioning of the late endocytic pathway and for long-range transport in axons.
- Location and functions of Inebriated in the Drosophila eye
Summary: Inebriated isoforms express in alternating glial layers of the Drosophila visual system, consistent with a role in histamine recycling in the eye, and its mutants exhibit blue light phototaxis defects.
- Characterization of a cdc14 null allele in Drosophila melanogaster
Summary: The Cdc14 phosphatase has been implicated in cell cycle regulation in S. cerevisiae. We show that Drosophila cdc14 mutants are viable, but exhibit defects in sperm competition, chemosensation, and mechanosensation.
- Female Drosophila melanogaster respond to song-amplitude modulations
Summary: We show that flies respond behaviourally to song amplitude structure; this observation suggests it may be a communication signal in Drosophila. We discuss our work in the broader context of other animals using amplitude modulations to communicate.
- The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle
Summary: This article has, for the first time, demonstrated that fruit fly TGF-beta, or Activin-type ligand Daw, or Myo-initiated Activin signaling in adult fruit fly muscle tissues works as an anti-ageing factor by regulating 26S proteasome activities in those tissues.
- miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila
Summary: Mir-9a overexpression can suppress the overgrowth phenotype caused by Lgl knock-down in epithelia. Gene profiling identifies pathways dysregulated in lgl mutants and shared features between flies and human cancer cells.