Drosophila
- miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila
Summary: Mir-9a overexpression can suppress the overgrowth phenotype caused by Lgl knock-down in epithelia. Gene profiling identifies pathways dysregulated in lgl mutants and shared features between flies and human cancer cells.
- Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila
Summary: RhoGEF3 is a developmentally regulated Cdc42 GEF that contributes to cortical stability during asymmetric divisions of Sensory Organ Precursor cells in Drosophila.
- Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner
Summary: This study examines the consequences of gain of cell fate selector genes in oncogenically targeted cells and reveals their two contrasting developmental context-dependent outcomes: namely, tumor cooperation and tumor inhibition.
- An AMPK-dependent regulatory pathway in tau-mediated toxicity
Summary: Dissection of the impact of AMPK and autophagy on tau-mediated toxicity by using an in vivo Drosophila tool as readout to perform preliminary drug screening supported by quantitative analyses.
- Specific expression and function of the Six3 optix in Drosophila serially homologous organs
Summary: The position of the Six3 optix is regulated by the Dpp pathway during wing and haltere development, and controls the size of both serially homologous organs.
- Investigation of protein synthesis in Drosophila larvae using puromycin labelling
Summary: This paper describes a simple approach, using puromycin-labelling of nascent peptides, to assay protein synthesis in response to growth and stress signals in Drosophila larvae.
- Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
Summary: Tau hyper-phosphorylation has been linked to toxicity, but the Tau isoforms, kinases and residues remain unclear. Using the Drosophila model, we find evidence for involvement of TTBK and MARK kinases.
- Dietary saccharides and sweet tastants have differential effects on colonization of Drosophila oocytes by Wolbachia endosymbionts
Summary: The density of Wolbachia infection in Drosophila oocytes is significantly increased by dietary sugars, but not sugar alcohols or artificial sweeteners.
- Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle
Summary: A map of subunit positional restrictions in Drosophila Augmin shows that Dgt3, Dgt5 and Dgt6 are all required to localise gamma-TuRC to mitotic spindles.
- Analysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kinetics
Summary: A novel method to directly visualize Hedgehog transport in the photoreceptor neurons of living animals offers unprecedented positional and temporal detail of complex phenotypes in real time.