Drosophila
- Female Drosophila melanogaster respond to song-amplitude modulations
Summary: We show that flies respond behaviourally to song amplitude structure; this observation suggests it may be a communication signal in Drosophila. We discuss our work in the broader context of other animals using amplitude modulations to communicate.
- The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle
Summary: This article has, for the first time, demonstrated that fruit fly TGF-beta, or Activin-type ligand Daw, or Myo-initiated Activin signaling in adult fruit fly muscle tissues works as an anti-ageing factor by regulating 26S proteasome activities in those tissues.
- miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila
Summary: Mir-9a overexpression can suppress the overgrowth phenotype caused by Lgl knock-down in epithelia. Gene profiling identifies pathways dysregulated in lgl mutants and shared features between flies and human cancer cells.
- Regulation of cortical stability by RhoGEF3 in mitotic Sensory Organ Precursor cells in Drosophila
Summary: RhoGEF3 is a developmentally regulated Cdc42 GEF that contributes to cortical stability during asymmetric divisions of Sensory Organ Precursor cells in Drosophila.
- Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner
Summary: This study examines the consequences of gain of cell fate selector genes in oncogenically targeted cells and reveals their two contrasting developmental context-dependent outcomes: namely, tumor cooperation and tumor inhibition.
- An AMPK-dependent regulatory pathway in tau-mediated toxicity
Summary: Dissection of the impact of AMPK and autophagy on tau-mediated toxicity by using an in vivo Drosophila tool as readout to perform preliminary drug screening supported by quantitative analyses.
- Specific expression and function of the Six3 optix in Drosophila serially homologous organs
Summary: The position of the Six3 optix is regulated by the Dpp pathway during wing and haltere development, and controls the size of both serially homologous organs.
- Investigation of protein synthesis in Drosophila larvae using puromycin labelling
Summary: This paper describes a simple approach, using puromycin-labelling of nascent peptides, to assay protein synthesis in response to growth and stress signals in Drosophila larvae.
- Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
Summary: Tau hyper-phosphorylation has been linked to toxicity, but the Tau isoforms, kinases and residues remain unclear. Using the Drosophila model, we find evidence for involvement of TTBK and MARK kinases.
- Dietary saccharides and sweet tastants have differential effects on colonization of Drosophila oocytes by Wolbachia endosymbionts
Summary: The density of Wolbachia infection in Drosophila oocytes is significantly increased by dietary sugars, but not sugar alcohols or artificial sweeteners.