Drosophila
- A genetically encoded biosensor for visualising hypoxia responses in vivo
Summary: This study describes a biosensor for visualising the hypoxic state of cells in vivo. They demonstrate that the Drosophila larval brain contains distinct hypoxic microenvironments that correlate with local airway supply.
- Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6
Summary: The spinocerebellar ataxia type 6 (SCA6) protein, α1ACT, causes polyglutamine length-dependent toxicity and aggregation in new Drosophila transgenic lines, opening the door for additional studies of this disease.
- Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells
Summary: Pulsed ecdysone signaling remodels cell cycle dynamics, causing distinct primary and secondary cell cycle arrests in Drosophila cells, analogous to those observed in the wing during metamorphosis.
- The impact of FOXO on dopamine and octopamine metabolism in Drosophila under normal and heat stress conditions
Summary: The transcription factor FOXO affects catecholamine metabolism under normal and heat stress conditions in D. melanogaster, and juvenile hormone (JH) is a mediator of this effect.
- Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning
Summary: The Drosophila homolog of pheromone convertase 2 (PC2), amontillado (Amon), is shown to contribute to Slit processing and further cleavage into an N-Slit, essential for Slit activity in directing muscle patterning.
- Comparative evaluation of the genomes of three common Drosophila-associated bacteria
Summary: We examined the genomes of Drosophila-associated bacteria to identify factors that allow survival within the host. These preliminary studies may point at bacterial products that influence host health.
- The role of acroblast formation during Drosophila spermatogenesis
Summary: This study demonstrates that retrograde tethering complexes are necessary to form a functional acroblast, which is essential for normal nuclear elongation and acrosome formation during Drosophila spermatogenesis.
- B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis
Summary: B-type lamin, positioned by nuclear pore component Nup107, strengthens the membranous intracellular structure supporting the microtubule bundles essential for cytokinesis in Drosophila male meiosis.
- An antibody toolkit for the study of membrane traffic in Drosophila melanogaster
Summary: We report the generation and characterization of set of monoclonal and polyclonal antibodies for labeling the major compartments of the secretory and endocytic pathways in Drosophila melanogaster.
- Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo
Summary: Pkaap has a dual role in antimicrobial peptide trafficking and exocytosis, making it an essential component for the secretion of inflammatory mediators and the defence of the host against pathogens.