ECM remodelling
- The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome
Summary: We report a novel sh3pxd2b mutant zebrafish model that develops cutaneous and musculoskeletal fibrosis, similar to that observed in people with Frank-Ter Haar syndrome.
- Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells
Summary: A 3D platform to characterise biomechanical remodelling of ECM by myofibroblast-like cells, using SHG microscopy, atomic force microscopy and quantitative algorithms to reveal structural, topological and mechanical properties of 3D matrices.