Epigenetics
- Defining the dynamic chromatin landscape of mouse nephron progenitors
Summary: An investigation of the chromatin landscape of mouse nephron progenitors across their life span supports the view that old nephron progenitors are epigenetically poised for differentiation.
- Meiosis in the scorpion Tityus silvestris: new insights into achiasmatic chromosomes
Summary: The scorpion Tityus silvestris, despite not presenting chiasma, performs initial stages of the recombination process and maintains the homologues synapse and different epigenetic modifications until late stages of meiosis I.
- KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation
Summary: The histone 3 lysine 4 demethylase KDM5B plays a key role in regulating H3K4 methylation during trophoblast stem cell self-renewal and differentiation. KDM5B regulates the transcriptional profile of TS cells during self-renewal and differentiation, and resets the H3K4 methylation landscape during differentiation by removing H3K4me3 from promoters of self-renewal and TS cell enriched genes.
- Vertically- and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria
Summary: In this hypothesis paper we re-evaluate canonical ideas about the interaction between developmental, genetic and evolutionary processes through the lens of planaria, an invertebrate model organism which challenges fundamental assumptions regarding reproduction.
- The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals
Summary: The triploid marbled crayfish is a rare animal example of speciation by autopolyploidisation and parthenogenesis. It seems to be a particularly suitable model to study how much genetic and epigenetic change is necessary to create a new species.
- Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity
Summary: This study provides new insights into the biological functions of a histone demethylase and sheds light on the interaction between epigenetic mechanisms and signaling pathways in regulating stem cell activities.