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Excitotoxicity

  • FUTURE LEADER REVIEW
    Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease
    Olayemi Joseph Olajide, Marcus E. Suvanto, Clifton Andrew Chapman
    Biology Open 2021 10: bio056796 doi: 10.1242/bio.056796 Published 25 January 2021

    Summary: This review evaluated the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.

  • RESEARCH ARTICLE
    Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus
    M. Troncoso, N. Bannoud, L. Carvelli, J. Asensio, A. Seltzer, M. A. Sosa
    Biology Open 2018 7: bio036723 doi: 10.1242/bio.036723 Published 25 October 2018

    Summary: Hypoxia ischemia (HI) induces an increase of gliosis and redistribution of prosaposin and cathepsin D into the cytosol of rat hippocampus. This could be triggered by LAMP-1 cleavage in HI.

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