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Extracellular matrix

  • RESEARCH ARTICLE
    MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β
    Chi-Yung Chai, I.-Chun Tai, Rui Zhou, Junlong Song, Chaoying Zhang, Shengrong Sun
    Biology Open 2020 9: bio051904 doi: 10.1242/bio.051904 Published 21 December 2020

    Summary: Our findings provided a new role of miR-9-5p/PPAR in the occurrence and development of HS fibroblasts, promising a new target for HS.

  • RESEARCH ARTICLE
    Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord
    Marcus May, Bernd Denecke, Timm Schroeder, Magdalena Götz, Andreas Faissner
    Biology Open 2018 7: bio027730 doi: 10.1242/bio.027730 Published 25 July 2018

    Summary: We have shown, using digital video microscopy based cell lineage tracing, that the glycoprotein of the extracellular matrix tenascin-C modulates growth factor responsiveness and cell cycle length of embryonic spinal cord progenitor cells in vitro.

  • RESEARCH ARTICLE
    Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster
    Ariane C. Wilmes, Nora Klinke, Barbara Rotstein, Heiko Meyer, Achim Paululat
    Biology Open 2018 7: bio030361 doi: 10.1242/bio.030361 Published 23 April 2018

    Summary: We identified two new pericardin alleles. Both mutants could be rescued with a genomic duplication of a fosmid coding for the pericardin locus. Biochemical analysis revealed that Pericardin is highly glycosylated and forms redox-dependent multimers.

  • RESEARCH ARTICLE
    Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion
    Shinichi Kawano, Takehiro Torisu, Motohiro Esaki, Kumiko Torisu, Yuichi Matsuno, Takanari Kitazono
    Biology Open 2017 6: 1644-1653; doi: 10.1242/bio.027458

    Summary: Autophagosomes localized close to internalized collagen and focal adhesions. In autophagy-deficient cells, internalized collagen and focal adhesion were increased, focal adhesion kinase signaling was impaired, and cell adhesion was enhanced.

  • RESEARCH ARTICLE
    An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix
    Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson
    Biology Open 2017 6: 1423-1433; doi: 10.1242/bio.025866

    Summary: Using an immunofluorescence extracellular matrix, we show that epithelial cells can deposit extracellular matrix components in a comparable manner to fibroblasts highlighting their role as potential targets in fibrotic disease.

  • RESEARCH ARTICLE
    CLASP1 regulates endothelial cell branching morphology and directed migration
    Nicole M. Myer, Kenneth A. Myers
    Biology Open 2017 6: 1502-1515; doi: 10.1242/bio.028571

    Summary: CLASP1 modulates microtubule dynamics with sub-cellular specificity in response to extracellular matrix density and composition. CLASP1 effects on microtubules promote short, branched protrusions that guide persistent and directional EC migration. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • RESEARCH ARTICLE
    Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae
    Jiankai Wei, Guilin Wang, Xiang Li, Ping Ren, Haiyan Yu, Bo Dong
    Biology Open 2017 6: 1383-1390; doi: 10.1242/bio.026336

    Summary: This study reveals the architecture, molecular composition and dynamic expression profile of the extracellular matrix in ascidian embryos and larvae, providing clues for its function in chordate development.

  • METHODS & TECHNIQUES
    A reporter mouse model for in vivo tracing and in vitro molecular studies of melanocytic lineage cells and their diseases
    Melissa Crawford, Valerie Leclerc, Lina Dagnino
    Biology Open 2017 6: 1219-1228; doi: 10.1242/bio.025833

    Summary: A reporter mouse to trace melanocytic lineage cells was generated by breeding existing mouse lines. Methods were also developed to characterize the proliferation and motility of primary mouse melanocytes.

  • RESEARCH ARTICLE
    Morphological diversity of blastula formation and gastrulation in temnopleurid sea urchins
    Chisato Kitazawa, Tsubasa Fujii, Yuji Egusa, Miéko Komatsu, Akira Yamanaka
    Biology Open 2016 5: 1555-1566; doi: 10.1242/bio.019018

    Summary: Closely related temnopleurid sea urchins exhibit diversity in blastula formation and gastrulation during early morphogenesis.

  • RESEARCH ARTICLE
    Eyes shut homolog is required for maintaining the ciliary pocket and survival of photoreceptors in zebrafish
    Miao Yu, Yu Liu, Jing Li, Brianna N. Natale, Shuqin Cao, Dongliang Wang, Jeffrey D. Amack, Huaiyu Hu
    Biology Open 2016 5: 1662-1673; doi: 10.1242/bio.021584

    Summary: The extracellular matrix protein Eyes shut homolog is required for maintaining the integrity of the ciliary pocket and survival of photoreceptors in zebrafish.

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