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F-actin

  • RESEARCH ARTICLE
    Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
    Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, António Jacinto
    Biology Open 2020 9: bio048629 doi: 10.1242/bio.048629 Published 3 May 2020

    Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.

  • RESEARCH ARTICLE
    F-actin reorganization by V-ATPase inhibition in prostate cancer
    Yamhilette Licon-Munoz, Vera Michel, Colleen A. Fordyce, Karlett J. Parra
    Biology Open 2017 6: 1734-1744; doi: 10.1242/bio.028837

    Summary: V-ATPase activates multiple stress responses. In prostate cancer, sub-lethal concentrations of V-ATPase inhibitors trigger widespread traffic defects. F-actin assembles into rings that mimic those seen during regulated exocytosis.

  • RESEARCH ARTICLE
    Apical constriction and epithelial invagination are regulated by BMP activity
    Vijay K. Jidigam, Raghuraman C. Srinivasan, Cedric Patthey, Lena Gunhaga
    Biology Open 2015 4: 1782-1791; doi: 10.1242/bio.015263

    Summary: We describe a novel role for BMP activity in promoting a direct and cell type-independent mechanism for apical constriction, cell elongation and epithelial invagination, separate from acquisition of placode-specific identities.

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