Heart development
- Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis
Summary: Targeted mutations were generated for each of the three gata4/5/6 genes in zebrafish to define functions for individual or combinations of these related transcription factors during cardiogenesis.
- Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly
Summary: The molecular mechanisms regulating cardiac fusion are not well understood. Here, we show that platelet-derived growth factor receptor alpha is essential for normal endocardial and myocardial fusion during zebrafish development.