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Biology Open

heart failure

RESEARCH ARTICLE

Enhanced store-operated Ca²⁺ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
Gracious R. Ross, Tanvir Bajwa, Jr, Stacie Edwards, Larisa Emelyanova, Farhan Rizvi, Ekhson L. Holmuhamedov, Paul Werner, Francis X. Downey, A. Jamil Tajik, Arshad Jahangir

Biology Open 2017 6: 326-332; doi: 10.1242/bio.022632

Summary: The excessive collagen secretory phenotype found in failing human hearts is associated with ventricular fibroblast remodeling, caused by an elevated influx of intracellular calcium via SOC channels.