Hypoxia
- Compartment and cell-type specific hypoxia responses in the developing Drosophila brain
Summary: A fluorescent biosensor reveals cell type specific hypoxia levels in the Drosophila brain in unprecedented detail. It paves the way for further functional studies addressing the role of oxygen in neural stem cell maintenance and differentiation.
- A methodological evaluation of the determination of critical oxygen threshold in an estuarine teleost
Summary: The two leading methods of measuring the critical oxygen threshold in fishes are similar in their estimations, regardless of changes to water chemistry.
- Identification of possible hypoxia sensor for behavioral responses in a marine annelid, Capitella teleta
Summary: The hypoxia-avoidance behavior of a marine annelid was suppressed by a TRPA1-specific inhibitor. Our dataset suggests that the possible hypoxia sensor for hypoxia-inducing behaviors of this marine annelid is TRPAbasal.
- Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice
Summary: We identified PDIA6 as a hypoxia-induced element of the unfolded protein response in cardiomyocytes and infarcted mouse hearts. PDIA6 expression and ejection fractions were reduced in infarcted ex-germ-free mouse hearts.
- Re-evaluating the functional landscape of the cardiovascular system during development
Summary: The body-wide landscape of the cardiovascular functions during development is reported. Such landscape may provide clues as to why the cardiovascular system is the first organ to develop.
- The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) enhances adaptation to a hypoxic environment
Summary: The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) increases anaerobic glycolysis, resulting in enhanced sprint-running capacity and adaptation to a hypoxic environment.
- Investigation of protein synthesis in Drosophila larvae using puromycin labelling
Summary: This paper describes a simple approach, using puromycin-labelling of nascent peptides, to assay protein synthesis in response to growth and stress signals in Drosophila larvae.
- The effects of moderate intensity training in a hypoxic environment on transcriptional responses in Thoroughbred horses
Summary: This was one of the first studies that examined transcriptional and physiological responses of Thoroughbred racehorses to six weeks moderate intensity treadmill training in a hypoxia chamber with 15% oxygen.
- Establishment of a retinal hypoxia organ culture model
Summary: An easy-to-use ex vivo retinal hypoxia model is introduced that reliably induced retinal damage on a morphological (retinal thickness), and molecular (protein expression and apoptotic markers) level.
- Dietary supplementation of heat-treated Gracilaria and Ulva seaweeds enhanced acute hypoxia tolerance in gilthead sea bream (Sparus aurata)
Summary: The physiological response and survival rate of gilthead sea bream to hypoxia was highly modulated by dietary supplementation of heat-treated seaweed.