Hypoxia
- A methodological evaluation of the determination of critical oxygen threshold in an estuarine teleost
Summary: The two leading methods of measuring the critical oxygen threshold in fishes are similar in their estimations, regardless of changes to water chemistry.
- Identification of possible hypoxia sensor for behavioral responses in a marine annelid, Capitella teleta
Summary: The hypoxia-avoidance behavior of a marine annelid was suppressed by a TRPA1-specific inhibitor. Our dataset suggests that the possible hypoxia sensor for hypoxia-inducing behaviors of this marine annelid is TRPAbasal.
- Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice
Summary: We identified PDIA6 as a hypoxia-induced element of the unfolded protein response in cardiomyocytes and infarcted mouse hearts. PDIA6 expression and ejection fractions were reduced in infarcted ex-germ-free mouse hearts.
- Re-evaluating the functional landscape of the cardiovascular system during development
Summary: The body-wide landscape of the cardiovascular functions during development is reported. Such landscape may provide clues as to why the cardiovascular system is the first organ to develop.
- The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) enhances adaptation to a hypoxic environment
Summary: The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) increases anaerobic glycolysis, resulting in enhanced sprint-running capacity and adaptation to a hypoxic environment.
- Investigation of protein synthesis in Drosophila larvae using puromycin labelling
Summary: This paper describes a simple approach, using puromycin-labelling of nascent peptides, to assay protein synthesis in response to growth and stress signals in Drosophila larvae.
- The effects of moderate intensity training in a hypoxic environment on transcriptional responses in Thoroughbred horses
Summary: This was one of the first studies that examined transcriptional and physiological responses of Thoroughbred racehorses to six weeks moderate intensity treadmill training in a hypoxia chamber with 15% oxygen.
- Establishment of a retinal hypoxia organ culture model
Summary: An easy-to-use ex vivo retinal hypoxia model is introduced that reliably induced retinal damage on a morphological (retinal thickness), and molecular (protein expression and apoptotic markers) level.
- Dietary supplementation of heat-treated Gracilaria and Ulva seaweeds enhanced acute hypoxia tolerance in gilthead sea bream (Sparus aurata)
Summary: The physiological response and survival rate of gilthead sea bream to hypoxia was highly modulated by dietary supplementation of heat-treated seaweed.
- Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
Summary: Induction of pulmonary microthrombosis by three distinct methods enhances HIF-a expression and tumour formation; increases in tumorigenesis that are induced by these thrombotic insults occur in a time- and mode-dependent manner.