Inflammation
- Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA
Summary: The availability of a reproducible animal model using current and clinically representative materials will facilitate translational research for innovative therapeutic approaches for prosthetic joint infections caused by Staphylococcus aureus.
- Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway
Summary: We prove that exogenous H2S can suppress NLRP3-mediated inflammation by promoting autophagy via the AMPK/mTOR pathway in L02 cells, providing insights into the anti-inflammatory mechanism of H2S.
- The mechanistic insight of a specific interaction between 15d-Prostaglandin-J2 and eIF4A suggests an evolutionary conserved role across species
Summary: The tail region of 15d-PGJ2 plays a important role in modulating the activity of eIF4A protein across species. This implies that the tail region of this prostaglandins can be adapted to design new drugs.
- Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue
Summary: Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue, involving -Akt, SPAK/JNK, and p38 MAPK which in turn are involved in Rac1 activation. Furthermore, these results augment our understanding of the insulin-regulated wound inflammatory response.
- Surviving murine experimental sepsis affects the function and morphology of the inner ear
Summary: This study shows that a mild sepsis leads to a significant hearing impairment due to apoptosis of different inner ear structures.
- IF-combined smRNA FISH reveals interaction of MCPIP1 protein with IER3 mRNA
Summary: We identify IER3 mRNA as a newly discovered MCPIP1 target using recently described IF-based procedures, and also identify a conserved element involved in MCPIP1-dependent IER3 transcript destabilization.
- Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma
Summary: This study describes a systematic analysis of molecular end points in an murine model of allergic asthma. The biosignature described can be used to interrogate molecular mechanisms and intervention strategies for airway inflammation pertinent to allergic asthma that precedes and possibly potentiates airway remodeling and fibrosis.