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Inflammation

  • FUTURE LEADER REVIEW
    Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease
    Olayemi Joseph Olajide, Marcus E. Suvanto, Clifton Andrew Chapman
    Biology Open 2021 10: bio056796 doi: 10.1242/bio.056796 Published 25 January 2021

    Summary: This review evaluated the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.

  • RESEARCH ARTICLE
    Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA
    Jodie L. Morris, Hayley L. Letson, Andrea Grant, Matthew Wilkinson, Kaushik Hazratwala, Peter McEwen
    Biology Open 2019 8: bio045203 doi: 10.1242/bio.045203 Published 18 September 2019

    Summary: The availability of a reproducible animal model using current and clinically representative materials will facilitate translational research for innovative therapeutic approaches for prosthetic joint infections caused by Staphylococcus aureus.

  • RESEARCH ARTICLE
    Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway
    Honggang Wang, Peiyu Zhong, Leilei Sun
    Biology Open 2019 8: bio043653 doi: 10.1242/bio.043653 Published 18 July 2019

    Summary: We prove that exogenous H2S can suppress NLRP3-mediated inflammation by promoting autophagy via the AMPK/mTOR pathway in L02 cells, providing insights into the anti-inflammatory mechanism of H2S.

  • RESEARCH ARTICLE
    The mechanistic insight of a specific interaction between 15d-Prostaglandin-J2 and eIF4A suggests an evolutionary conserved role across species
    So Jeong Yun, Hyunjoon Kim, Seung-Hyun Jung, Joon Hyun Kim, Jeong Eun Ryu, N. Jiten Singh, Jouhyun Jeon, Jin-Kwan Han, Cheol-Hee Kim, Sanguk Kim, Sung Key Jang, Woo Jae Kim
    Biology Open 2018 7: bio035402 doi: 10.1242/bio.035402 Published 13 November 2018

    Summary: The tail region of 15d-PGJ2 plays a important role in modulating the activity of eIF4A protein across species. This implies that the tail region of this prostaglandins can be adapted to design new drugs.

  • RESEARCH ARTICLE
    Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue
    Yan Liu, Sandeep Dhall, Anthony Castro, Alex Chan, Raquelle Alamat, Manuela Martins-Green
    Biology Open 2018 7: bio026187 doi: 10.1242/bio.026187 Published 17 January 2018

    Summary: Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue, involving -Akt, SPAK/JNK, and p38 MAPK which in turn are involved in Rac1 activation. Furthermore, these results augment our understanding of the insulin-regulated wound inflammatory response.

  • RESEARCH ARTICLE
    Surviving murine experimental sepsis affects the function and morphology of the inner ear
    Natalie Fischer, Nina Maria Mathonia, Georges Hollerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard
    Biology Open 2017 6: 732-740; doi: 10.1242/bio.024588

    Summary: This study shows that a mild sepsis leads to a significant hearing impairment due to apoptosis of different inner ear structures.

  • RESEARCH ARTICLE
    IF-combined smRNA FISH reveals interaction of MCPIP1 protein with IER3 mRNA
    Jakub Kochan, Mateusz Wawro, Aneta Kasza
    Biology Open 2016 5: 889-898; doi: 10.1242/bio.018010

    Summary: We identify IER3 mRNA as a newly discovered MCPIP1 target using recently described IF-based procedures, and also identify a conserved element involved in MCPIP1-dependent IER3 transcript destabilization.

  • RESEARCH ARTICLE
    Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma
    Hadeesha Piyadasa, Anthony Altieri, Sujata Basu, Jacquie Schwartz, Andrew J. Halayko, Neeloffer Mookherjee
    Biology Open 2016 5: 112-121; doi: 10.1242/bio.014464

    Summary: This study describes a systematic analysis of molecular end points in an murine model of allergic asthma. The biosignature described can be used to interrogate molecular mechanisms and intervention strategies for airway inflammation pertinent to allergic asthma that precedes and possibly potentiates airway remodeling and fibrosis.

  • RESEARCH ARTICLE
    A zebrafish model of inflammatory lymphangiogenesis
    Kazuhide S. Okuda, June Pauline Misa, Stefan H. Oehlers, Christopher J. Hall, Felix Ellett, Sultan Alasmari, Graham J. Lieschke, Kathryn E. Crosier, Philip S. Crosier, Jonathan W. Astin
    Biology Open 2015 4: 1270-1280; doi: 10.1242/bio.013540
  • RESEARCH ARTICLE
    Apolipoprotein CIII regulates lipoprotein-associated phospholipase A2 expression via the MAPK and NFκB pathways
    Xiaolei Han, Tiedong Wang, Jifeng Zhang, Xingxing Liu, Zhuang Li, Gangqi Wang, Qi Song, Daxin Pang, Hongsheng Ouyang, Xiaochun Tang
    Biology Open 2015 4: 661-665; doi: 10.1242/bio.201410900

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