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LPS

  • RESEARCH ARTICLE
    Neuronal changes and cognitive deficits in a multi-hit rat model following cumulative impact of early life stressors
    Tiyasha Sarkar, Nisha Patro, Ishan Kumar Patro
    Biology Open 2020 9: bio054130 doi: 10.1242/bio.054130 Published 24 September 2020

    Summary: This study is the first of its kind that practically investigated the combined exposure of major early life stressors like protein malnourishment and viral and bacterial infections on the nervous system.

  • RESEARCH ARTICLE
    Pioglitazone abolishes cognition impairments as well as BDNF and neurotensin disturbances in a rat model of autism
    Thiago B. Kirsten, Renato C. Casarin, Maria M. Bernardi, Luciano F. Felicio
    Biology Open 2019 8: bio041327 doi: 10.1242/bio.041327 Published 13 May 2019

    Summary: Exposure of rats to lipopolysaccharide during gestation induced autistic-like behaviors in the juvenile offspring. Daily postnatal pioglitazone treatment abolished cognition impairments as well as brain-derived neurotrophic factor and neurotensin disturbances.

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