Mitochondria
- Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.
- Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.
- Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
Summary: Enhancing mitochondria–ER contacts ameliorates locomotor phenotypes and extends lifespan in a fly model of Alzheimer's disease.
- Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
Summary: Mitochondrial calcium overload causes mitochondrial dysfunction in Parkinson's disease. Inactivation of mitochondrial calcium uniporter reverses mitochondrial calcium overload and rescues dopaminergic neurons in our zebrafish models of Parkinson's disease.
- Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model
Summary: Overexpression of spargel, the fly PGC-1 homologue proposed as a mitochondrial biogenesis regulator, has minimal effects on the phenotype of tko25t, considered a fly model for mitochondrial disease.
- Detection of changes in mitochondrial hydrogen sulfide in vivo in the fish model Poecilia mexicana (Poeciliidae)
Summary: We established the mitochondria-targeted mass spectrometry probe MitoA for H2S detection in vivo in the animal model Poecilia mexicana for the first time.
- Gcn5 histone acetyltransferase is present in the mitoplasts
Summary: In yeast mitochondria the Gcn5 protein is present in the mitoplasts and is localized in the inner mitochondrial membrane. Its deletion affects the mitochondrial phenotype and is related to a marked decrease of mitochondrial DNA content.
- The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
Summary: A novel mitochondrial DNA mutator murine embryonic fibroblast cell line was created and the effects of the anti-aging compounds rapamycin and AICAR on energy metabolism in these cells was determined.
- Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development
Summary: We characterised subtype-specific growth of the different photoreceptor compartments, organelle distribution and the influence of light on the growth of the apical membrane.
- Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes
Summary: We assessed the effect of cytoskeletal inhibitors and the use of a calcium ionophore as an additional stressor on mitochondrial motility and bioenergetic function in fibroblasts and fibrosarcoma cells.