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Mitochondria

  • RESEARCH ARTICLE
    CD47 differentially regulates white and brown fat function
    Heather Norman-Burgdolf, Dong Li, Patrick Sullivan, Shuxia Wang
    Biology Open 2020 9: bio056747 doi: 10.1242/bio.056747 Published 16 December 2020

    Summary: Under physiological conditions, CD47 differentially regulates white fat and brown fat function. Through a coordinated manner, altered fuel availability via white adipose tissue lipolysis may influence brown adipose tissue energy expenditure and then body weight management.

  • RESEARCH ARTICLE
    Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue
    Li-jie Wang, Tian Hsu, Hsiang-ling Lin, Chi-yu Fu
    Biology Open 2020 9: bio054262 doi: 10.1242/bio.054262 Published 3 December 2020

    Summary: Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue.

  • RESEARCH ARTICLE
    Miro, a Rho GTPase genetically interacts with Alzheimer's disease-associated genes (Tau, Aβ42 and Appl) in Drosophila melanogaster
    Komal Panchal, Anand Krishna Tiwari
    Biology Open 2020 9: bio049569 doi: 10.1242/bio.049569 Published 3 September 2020

    Summary: Our study suggests that overexpression of Miro improves the Alzheimer's disease-related pathologies by decreasing the rough eye phenotype, oxidative stress, apoptosis and neurodegeneration and increasing the lifespan, body weight, phototaxis and climbing activity in the Drosophila model of Alzheimer's disease.

  • RESEARCH ARTICLE
    Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing
    Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, António Jacinto
    Biology Open 2020 9: bio048629 doi: 10.1242/bio.048629 Published 3 May 2020

    Summary: We show that mitochondrial dynamics proteins are required for epithelial repair. Drp1 loss-of-function leads to defects in the dynamics of cytosolic and mitochondrial calcium, ROS production and F-actin upon wounding.

  • RESEARCH ARTICLE
    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
    Biology Open 2020 9: bio047530 doi: 10.1242/bio.047530 Published 14 January 2020

    Summary: Enhancing mitochondria–ER contacts ameliorates locomotor phenotypes and extends lifespan in a fly model of Alzheimer's disease.

  • RESEARCH ARTICLE
    Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
    Smijin K. Soman, Michal Bazała, Marcus Keatinge, Oliver Bandmann, Jacek Kuznicki
    Biology Open 2019 8: bio044347 doi: 10.1242/bio.044347 Published 15 October 2019

    Summary: Mitochondrial calcium overload causes mitochondrial dysfunction in Parkinson's disease. Inactivation of mitochondrial calcium uniporter reverses mitochondrial calcium overload and rescues dopaminergic neurons in our zebrafish models of Parkinson's disease.

  • RESEARCH ARTICLE
    Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model
    Jack George, Howard T. Jacobs
    Biology Open 2019 8: bio042135 doi: 10.1242/bio.042135 Published 19 July 2019

    Summary: Overexpression of spargel, the fly PGC-1 homologue proposed as a mitochondrial biogenesis regulator, has minimal effects on the phenotype of tko25t, considered a fly model for mitochondrial disease.

  • METHODS & TECHNIQUES
    Detection of changes in mitochondrial hydrogen sulfide in vivo in the fish model Poecilia mexicana (Poeciliidae)
    Gigi Y. Lau, Nicholas Barts, Richard C. Hartley, Michael Tobler, Jeffrey G. Richards, Michael P. Murphy, Sabine Arndt
    Biology Open 2019 8: bio041467 doi: 10.1242/bio.041467 Published 9 May 2019

    Summary: We established the mitochondria-targeted mass spectrometry probe MitoA for H2S detection in vivo in the animal model Poecilia mexicana for the first time.

  • RESEARCH ARTICLE
    Gcn5 histone acetyltransferase is present in the mitoplasts
    Arianna Montanari, Manuela Leo, Veronica De Luca, Patrizia Filetici, Silvia Francisci
    Biology Open 2019 8: bio041244 doi: 10.1242/bio.041244 Published 18 February 2019

    Summary: In yeast mitochondria the Gcn5 protein is present in the mitoplasts and is localized in the inner mitochondrial membrane. Its deletion affects the mitochondrial phenotype and is related to a marked decrease of mitochondrial DNA content.

  • RESEARCH ARTICLE
    The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
    Vedad Delic, Kenyaria Noble, Sandra Zivkovic, Tam-Anh Phan, Christian Reynes, Yumeng Zhang, Oluwakemi Phillips, Charles Claybaker, Yen Ta, Vinh B. Dinh, Josean Cruz, Tomas A. Prolla, Patrick C. Bradshaw
    Biology Open 2018 7: bio033852 doi: 10.1242/bio.033852 Published 16 November 2018

    Summary: A novel mitochondrial DNA mutator murine embryonic fibroblast cell line was created and the effects of the anti-aging compounds rapamycin and AICAR on energy metabolism in these cells was determined.

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