Mitochondria
- Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease
Summary: Dietary supplementation with an NAD+ salvage metabolite or decreasing Parp activity suppress mitochondrial dysfunction and is neuroprotective in a PINK1 model of Parkinson's disease.
- Chicken muscle mitochondrial content appears co-ordinately regulated and is associated with performance phenotypes
Summary: We have detected variation in muscle mitochondrial content across chickens. This variation relates to phenotypes and also indicates coordinate regulation of mitochondrial biogenesis across the musculature.
- Hypersalinity drives physiological and morphological changes in Limia perugiae (Poeciliidae)
Summary: A population of Limia perugiae living in hypersalinity shows modifications to osmoregulatory mechanisms, correlated with changes to body size, morphology of the head, and secondary sex features.
- Expression and preliminary characterization of human MICU2
Summary: Ca2+ induces a monomer-dimer switch of MICU2, with the associated conformational change governed by its first EF-hand, but not influenced by the C-helix domain. A disulfide bond and salt bridge each contribute to MICU1-MICU2 heterodimer formation.
- Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina)
Summary: Unlike endothermic species, there is little change in skeletal and cardiac muscle mitochondrial function from the embryonic stage through the first year of life in ectothermic alligators and snapping turtles.
- Clueless is a conserved ribonucleoprotein that binds the ribosome at the mitochondrial outer membrane
Summary: Clueless is a ribonucleoprotein that is crucial for mitochondrial function. Here we show Clueless can bind the ribosome at the mitochondrial outer membrane, suggesting it may play a role in mitochondrial co-translational import.
- Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways
Summary: Highly polarized Drosophila bristle cells reveal that dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways, and a novel mode of coordination between Khc and Dhc in mitochondrial transport.