mTOR
- The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
Summary: A novel mitochondrial DNA mutator murine embryonic fibroblast cell line was created and the effects of the anti-aging compounds rapamycin and AICAR on energy metabolism in these cells was determined.
- Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function
Summary: We exploit the BioGRID gene interaction database to identify and characterize susceptibilities in fission yeast cells lacking tsc1 or tsc2, orthologs of the human TSC1 and TSC2 tumor suppressor genes.