Neural stem cells
- Distinct gene-selective roles for a network of core promoter factors in Drosophila neural stem cell identity
Summary: A subset of TAFs has been identified as regulators of NSC identity in Drosophila, which could inform human neurological disorders linked to TAF variants.
- Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
Summary: Upon large-scale brain excision in adult newts, the outcome of structural regeneration of the brain cytoarchitecture depends on ways of closing the wound by NSCs residing between brain subregions.
- Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
Summary: Injecting hiNSCs into developing chick brains and systemically infecting with ZIKV produces embryos with severe microcephaly. Using this humanized model we show that niclosamide rescues ZIKV-induced microcephaly and decreases infection of hiNSCs in vivo.