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Neural stem cells

  • METHODS & TECHNIQUES
    Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids
    Roberta Azzarelli, Michela Ori, Anna Philpott, Benjamin D. Simons
    Biology Open 2021 10: bio056416 doi: 10.1242/bio.056416 Published 22 February 2021

    Summary: We describe a method to co-culture glioblastoma stem cells with human cerebral organoids in order to model tumor complexity and recapitulate cellular heterogeneity in vitro.

  • RESEARCH ARTICLE
    Distinct gene-selective roles for a network of core promoter factors in Drosophila neural stem cell identity
    Alexandre Neves, Robert N. Eisenman
    Biology Open 2019 8: bio042168 doi: 10.1242/bio.042168 Published 4 April 2019

    Summary: A subset of TAFs has been identified as regulators of NSC identity in Drosophila, which could inform human neurological disorders linked to TAF variants.

  • RESEARCH ARTICLE
    Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
    Yuko Urata, Wataru Yamashita, Takeshi Inoue, Kiyokazu Agata
    Biology Open 2018 7: bio033142 doi: 10.1242/bio.033142 Published 25 June 2018

    Summary: Upon large-scale brain excision in adult newts, the outcome of structural regeneration of the brain cytoarchitecture depends on ways of closing the wound by NSCs residing between brain subregions.

  • RESEARCH ARTICLE
    Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
    Dana M. Cairns, Devi Sai Sri Kavya Boorgu, Michael Levin, David L. Kaplan
    Biology Open 2018 7: bio031807 doi: 10.1242/bio.031807 Published 29 January 2018

    Summary: Injecting hiNSCs into developing chick brains and systemically infecting with ZIKV produces embryos with severe microcephaly. Using this humanized model we show that niclosamide rescues ZIKV-induced microcephaly and decreases infection of hiNSCs in vivo.

  • RESEARCH ARTICLE
    The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin
    Tamara Holowacz, Tania O. Alexson, Brenda L. Coles, Bradley W. Doble, Kevin F. Kelly, James R. Woodgett, Derek Van Der Kooy
    Biology Open 2013 2: 812-821; doi: 10.1242/bio.20131941

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