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Neurogenesis

  • METHODS & TECHNIQUES
    Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids
    Roberta Azzarelli, Michela Ori, Anna Philpott, Benjamin D. Simons
    Biology Open 2021 10: bio056416 doi: 10.1242/bio.056416 Published 22 February 2021

    Summary: We describe a method to co-culture glioblastoma stem cells with human cerebral organoids in order to model tumor complexity and recapitulate cellular heterogeneity in vitro.

  • RESEARCH ARTICLE
    Cell-extrinsic requirement for sulfate in regulating hippocampal neurogenesis
    Zhe Zhang, Dhanisha Jhaveri, Sazia Sharmin, Tracey J. Harvey, Paul A. Dawson, Michael Piper, David G. Simmons
    Biology Open 2020 9: bio053132 doi: 10.1242/bio.053132 Published 31 July 2020

    Summary Statement: Heterozygosity for the brain sulfate transporter Slc13a4 during postnatal development results in life-long abnormal hippocampal neurogenesis.

  • RESEARCH ARTICLE
    Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism
    Hector G. Gomez, Hirofumi Noguchi, Jesse Garcia Castillo, David Aguilar, Samuel J. Pleasure, Odessa R. Yabut
    Biology Open 2019 8: bio039248 doi: 10.1242/bio.039248 Published 6 June 2019

    Summary: Conditional deletion of Sufu causes dramatic expansion of neural stem/precursor cells in the neonatal ventricular-subventricular (SVZ) zone. This defect occurs through a Gli3-dependent mechanism resulting in the downregulation of Shh signaling.

  • RESEARCH ARTICLE
    Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development
    Lata Adnani, Rajiv Dixit, Xingyu Chen, Anjali Balakrishnan, Harshil Modi, Yacine Touahri, Cairine Logan, Carol Schuurmans
    Biology Open 2018 7: bio038661 doi: 10.1242/bio.038661 Published 26 November 2018

    Summary: Plag1 and Plagl2 are proto-oncogenes that have been studied extensively in cancer. Here we provide the first report of a role for these genes in the developing central nervous system.

  • RESEARCH ARTICLE
    Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
    Yuko Urata, Wataru Yamashita, Takeshi Inoue, Kiyokazu Agata
    Biology Open 2018 7: bio033142 doi: 10.1242/bio.033142 Published 25 June 2018

    Summary: Upon large-scale brain excision in adult newts, the outcome of structural regeneration of the brain cytoarchitecture depends on ways of closing the wound by NSCs residing between brain subregions.

  • RESEARCH ARTICLE
    A dual role of the extracellular domain of Drosophila Crumbs for morphogenesis of the embryonic neuroectoderm
    Shradha Das, Elisabeth Knust
    Biology Open 2018 7: bio031435 doi: 10.1242/bio.031435 Published 26 January 2018

    Summary: Using a transgenomic approach we determine specific roles of the intra- and extracellular domain of the Crumbs protein for the maintenance of apico-basal epithelial polarity and epithelial morphogenesis in Drosophila embryos.

  • RESEARCH ARTICLE
    Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development
    Simone Schwarzer, Sandra Spieß, Michael Brand, Stefan Hans
    Biology Open 2017 6: 1270-1278; doi: 10.1242/bio.026211

    Summary: The transcription factors Dlx3b and Dlx4b control the formation of early-born sensory hair cells or tether cells in the developing zebrafish inner ear.

  • RESEARCH ARTICLE
    Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain
    Niurka Trujillo-Paredes, Concepción Valencia, Gilda Guerrero-Flores, Dulce-María Arzate, José-Manuel Baizabal, Magdalena Guerra-Crespo, Ayari Fuentes-Hernández, Iván Zea-Armenta, Luis Covarrubias
    Biology Open 2016 5: 336-347; doi: 10.1242/bio.013383

    Summary: The early emergence of dopaminergic neurons under reduced Notch signalling results from a change in the differentiation flux that defines the final number of neurons produced.

  • RESEARCH ARTICLE
    Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism
    Gabriel N. Aughey, Stuart J. Grice, Qing-Ji Shen, Yichi Xu, Chia-Chun Chang, Ghows Azzam, Pei-Yu Wang, Luke Freeman-Mills, Li-Mei Pai, Li-Ying Sung, Jun Yan, Ji-Long Liu
    Biology Open 2014 3: 1045-1056; doi: 10.1242/bio.201410165
  • RESEARCH ARTICLE
    p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex
    Camille Belzil, Naoyuki Asada, Kei-ichiro Ishiguro, Takeo Nakaya, Kari Parsons, Valentina Pendolino, Gernot Neumayer, Marina Mapelli, Yoshihiro Nakatani, Kamon Sanada, Minh Dang Nguyen
    Biology Open 2014 3: 475-485; doi: 10.1242/bio.20147807

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