Neurogenesis
- Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism
Summary: Conditional deletion of Sufu causes dramatic expansion of neural stem/precursor cells in the neonatal ventricular-subventricular (SVZ) zone. This defect occurs through a Gli3-dependent mechanism resulting in the downregulation of Shh signaling.
- Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development
Summary: Plag1 and Plagl2 are proto-oncogenes that have been studied extensively in cancer. Here we provide the first report of a role for these genes in the developing central nervous system.
- Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
Summary: Upon large-scale brain excision in adult newts, the outcome of structural regeneration of the brain cytoarchitecture depends on ways of closing the wound by NSCs residing between brain subregions.
- A dual role of the extracellular domain of Drosophila Crumbs for morphogenesis of the embryonic neuroectoderm
Summary: Using a transgenomic approach we determine specific roles of the intra- and extracellular domain of the Crumbs protein for the maintenance of apico-basal epithelial polarity and epithelial morphogenesis in Drosophila embryos.
- Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development
Summary: The transcription factors Dlx3b and Dlx4b control the formation of early-born sensory hair cells or tether cells in the developing zebrafish inner ear.
- Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain
Summary: The early emergence of dopaminergic neurons under reduced Notch signalling results from a change in the differentiation flux that defines the final number of neurons produced.