Nucleolus
- Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization
Summary: Stress conditions, including DNA damaging agents, and knockdown of nuclear proteins, including SMN and Drosha, alter the processing dynamics of scaRNA 2 and 9.
- Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
Summary: The major contributor to ribosome heterogeneity is variation in rRNA modification by methylation and pseudouridylation. Our work provides additional evidence for the regulation of snoRNP activity by regRNPs, which alters levels of methylation.
- Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity
Summary: Processed scaRNAs give rise to a novel regulatory RNP, which regulates the modification of ribosomal RNA. These findings provide insight into the mechanisms governing ribosome heterogeneity.