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Nucleolus

  • RESEARCH ARTICLE
    Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization
    Madelyn K. Logan, Marilyn F. Burke, Michael D. Hebert
    Biology Open 2018 7: bio037101 doi: 10.1242/bio.037101 Published 27 September 2018

    Summary: Stress conditions, including DNA damaging agents, and knockdown of nuclear proteins, including SMN and Drosha, alter the processing dynamics of scaRNA 2 and 9.

  • RESEARCH ARTICLE
    Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation
    Marilyn F. Burke, Madelyn K. Logan, Michael D. Hebert
    Biology Open 2018 7: bio036095 doi: 10.1242/bio.036095 Published 10 August 2018

    Summary: The major contributor to ribosome heterogeneity is variation in rRNA modification by methylation and pseudouridylation. Our work provides additional evidence for the regulation of snoRNP activity by regRNPs, which alters levels of methylation.

  • RESEARCH ARTICLE
    Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity
    Aaron R. Poole, Ian Vicino, Hironori Adachi, Yi-Tao Yu, Michael D. Hebert
    Biology Open 2017 6: 1342-1354; doi: 10.1242/bio.028092

    Summary: Processed scaRNAs give rise to a novel regulatory RNP, which regulates the modification of ribosomal RNA. These findings provide insight into the mechanisms governing ribosome heterogeneity.

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