Ototoxicity
- The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death
Summary: Here we show that both retrograde intraflagellar transport motor proteins and IFT-A adaptor molecules play a role in aminoglycoside-induced hair cell death, seemingly through regulating aminoglycoside uptake.
- Activation of PI3K signaling prevents aminoglycoside-induced hair cell death in the murine cochlea
Summary: Activation of PI3K signaling using either a pharmacological inhibitor or genetic ablation of PTEN protects inner ear hair cells from aminoglycoside-induced death.