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Biology Open

Plasminogen

RESEARCH ARTICLE

Biochemical and histological evidence of deteriorated bioprosthetic valve leaflets: the accumulation of fibrinogen and plasminogen
Tomohisa Sakaue, Hirotomo Nakaoka, Fumiaki Shikata, Jun Aono, Mie Kurata, Teruyoshi Uetani, Mika Hamaguchi, Ai Kojima, Shunji Uchita, Takumi Yasugi, Haruhiko Higashi, Jun Suzuki, Shuntaro Ikeda, Jitsuo Higaki, Shigeki Higashiyama, Hironori Izutani

Biology Open 2018 7: bio034009 doi: 10.1242/bio.034009 Published 8 August 2018

Summary: Fibrinogen was specifically deposited on whole deteriorated tissue valve leaflets, and plasminogen-positive macrophages strongly invaded the areas around calcified bioprosthetic and native tissues.