Primary cilia
- RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner
Summary: RPGR is a ciliary protein that functions as a scaffold to recruit cargo-loaded PDE6D to cilia. Our study shows that RPGR is also a cargo of PDE6D.
- The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling
Summary: Primary cilia stiffness can be modulated, affecting the cellular responsiveness to mechanical signals. We identify a potential mechanism that regulates cellular mechanosensitivity.